ArticleEvidence-based complementary and alternative medicine : eCAM2012
Understanding the molecular mechanism of interventions in treating rheumatoid arthritis patients with corresponding traditional chinese medicine patterns based on bioinformatics approach.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Short-term efficacy of treating hepatitis B virus-related acute-on-chronic liver failure based on cold pattern differentiation with hot herbs: A randomized controlled trial.Chinese journal of integrative medicine · 2016Trial
- Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial.Scientific reports · 2015Trial
- Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis.Chinese medicine · 2023Article
- Targets preliminary screening for the fresh natural drug molecule based on Cosine-correlation and similarity-comparison of local network.Journal of translational medicine · 2022Article
- A Novel Drug Combination of Mangiferin and Cinnamic Acid Alleviates Rheumatoid Arthritis by Inhibiting TLR4/NFκB/NLRP3 Activation-Induced Pyroptosis.Frontiers in immunology · 2022Article
- Understanding Chinese Medicine Patterns of Rheumatoid Arthritis and Related Biomarkers.Medicines (Basel, Switzerland) · 2018Review
- CytoCluster: A Cytoscape Plugin for Cluster Analysis and Visualization of Biological Networks.International journal of molecular sciences · 2017Article
- Resveratrol (3,5,4'-trihydroxystilbene) and its properties in oral diseases.Experimental and therapeutic medicine · 2017Article
- Systems Biology - A Pivotal Research Methodology for Understanding the Mechanisms of Traditional Medicine.Journal of pharmacopuncture · 2015Review
- Navigating traditional chinese medicine network pharmacology and computational tools.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Traditional chinese medicine-based network pharmacology could lead to new multicompound drug discovery.Evidence-based complementary and alternative medicine : eCAM · 2012Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Better effectiveness would be achieved when interventions are used in treating patients with a specific traditional Chinese medicine (TCM) pattern. In this paper, the effectiveness in treating rheumatoid arthritis (RA) patients in a randomized clinical trial as reanalyzed after the patients were classified into different TCM patterns and the underlying mechanism of how the TCM pattern influences the clinical effectiveness of interventions (TCM and biomedicine therapy) was explored. The pharmacological networks of interventions were builtup with protein and protein interaction analyses based on all the related targeted proteins obtained from PubChem. The underlying mechanism was explored by merging the pharmacological networks with the molecular networks of TCM cold and hot patterns in RA. The results show that the TCM therapy is better in treating the RA patients with TCM hot pattern, and the biomedical therapy is better in the RA patients with cold pattern. The pharmacological network of TCM intervention is merged well with the molecular network of TCM hot pattern, and the pharmacological network of biomedical therapy is merged well with the network of cold pattern. The finding indicates that molecular network analysis could give insight into the full understanding of the underlying mechanism of how TCM pattern impacts the efficacy.
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Registered trials
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