Evidence map›Paper›PMID 23118713›Full record

ArticleMarine drugs2012

Characterization of isoforms of the lectin isolated from the red algae Bryothamnion seaforthii and its pro-healing effect.

Luiz Gonzaga do Nascimento-Neto, Romulo Farias Carneiro, Suzete Roberta Da Silva, Bruno Rocha Da Silva, Francisco Vassiliepe Sousa Arruda, Victor Alves Carneiro, Kyria Santiago Do Nascimento, Silvana Saker-Sampaio, Valdemiro Amaro Da Silva, Ana Lúcia Figueiredo Porto and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Antifungal activity ofCurrent medical mycology · 2023
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Lectins from red algae and their biomedical potential.Journal of applied phycology · 2018
    Review
  8. Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications.Evidence-based complementary and alternative medicine : eCAM · 2017
    Review
  9. Marine lectins and their medicinal applications.Applied microbiology and biotechnology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luiz Gonzaga do Nascimento-NetoLIBS, Integrated Laboratory of Biomolecules, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Romulo Farias CarneiroBioMol, Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Suzete Roberta Da SilvaBioMar, Laboratory of Marine Biotechnology, Department of Fishing Engineering, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Bruno Rocha Da SilvaLIBS, Integrated Laboratory of Biomolecules, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Francisco Vassiliepe Sousa ArrudaLIBS, Integrated Laboratory of Biomolecules, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Victor Alves CarneiroBioMol, Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Kyria Santiago Do NascimentoBioMol, Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Silvana Saker-SampaioBioMar, Laboratory of Marine Biotechnology, Department of Fishing Engineering, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Valdemiro Amaro Da SilvaDepartment of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco 52071-030, Brazil.
Ana Lúcia Figueiredo PortoDepartment of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife, Pernambuco 52071-030, Brazil.
Benildo Sousa CavadaBioMol, Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Alexandre Holanda SampaioBioMar, Laboratory of Marine Biotechnology, Department of Fishing Engineering, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Edson Holanda TeixeiraLIBS, Integrated Laboratory of Biomolecules, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.
Celso Shiniti NaganoBioMar, Laboratory of Marine Biotechnology, Department of Fishing Engineering, Federal University of Ceará, Fortaleza, CE 60020-181, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lectins are a structurally heterogeneous group of proteins that have specific binding sites for carbohydrates and glycoconjugates. Because of their biotechnological potential, lectins are widely used in biomedical research. The present study aimed to evaluate the healing potential of the lectin isolated from the marine red alga Bryothamnion seaforthii (BSL). The lectin was purified using ion exchange chromatography with DEAE cellulose and characterized using tandem mass spectrometry. For healing tests, skin wounds were induced in the dorsal thoracic region of mice. These animals were randomly divided into three groups and subjected to topical treatment for 12 days with BSL, bovine serum albumin and 150 mM NaCl. To evaluate the potential of each treatment, the animals were anesthetized and sacrificed on days 2, 7 and 12, respectively. The parameters evaluated included the wound area, the proportion of wound closure and the histological diagnosis. The wound closure was more effective with BSL (Postoperative Day 7 and 12) than controls. The luminal epithelium was completely restructured; the presence of collagen in the dermis and the strongly active presence of young skin annexes demonstrate the potential of treatment with BSL compared with controls. Our findings suggest that BSL has pro-healing properties and can be a potential medical process in the treatment of acute wounds.

Indexed as

Amino Acid SequenceAnimalsDermisLectinsMaleMiceMolecular Sequence DataProtein IsoformsRhodophytaSequence Analysis, ProteinWound HealingLectinsProtein Isoformsalgal proteinslectinswound healing

Identifiers

PMID23118713
PMCPMC3475265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.