ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2012
Chloramphenicol toxicity revisited: a 12-year-old patient with a brain abscess.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Cross-Sector Antimicrobial Resistance and Virulence inAntibiotics (Basel, Switzerland) · 2026Article
- Underprescription of Clozapine: A Narrative Review Regarding 'Clozaphobia'.Human psychopharmacology · 2026Review
- Chloramphenicol-induced gray baby syndrome: case report and review of current literature.Frontiers in pediatrics · 2025Article
- Potential protection by vitamin D against DNA fragmentation and bone marrow cytotoxicity induced by chloramphenicol.Toxicology reports · 2024Article
- Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity.Structure (London, England : 1993) · 2024Article
- Obtaining New Biocompatible Composite Materials with Antibacterial Properties Based on Diatomite and Biologically Active Compounds.Molecules (Basel, Switzerland) · 2024Article
- Enhancing the Efficacy of Chloramphenicol Therapy forAntibiotics (Basel, Switzerland) · 2024Article
- Proteomic Analysis of the Mitochondrial Responses in P19 Embryonic Stem Cells Exposed to Florfenicol.Toxics · 2023Article
- Laboratory indices of hospitalized sickle cell disease patients, prevalence and antimicrobial susceptibility of pathogenic bacterial isolates at MRCG ward in the Gambia.BMC infectious diseases · 2023Article
- Phytochemicals as Antimicrobials: Prospecting Himalayan Medicinal Plants as Source of Alternate Medicine to Combat Antimicrobial Resistance.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Cyclodextrin Inclusion Complexes with Antibiotics and Antibacterial Agents as Drug-Delivery Systems-A Pharmaceutical Perspective.Pharmaceutics · 2022Review
- Microbial Acoustical Analyzer for Antibiotic Indication.Sensors (Basel, Switzerland) · 2022Article
- Occurrence, toxicity and adsorptive removal of the chloramphenicol antibiotic in water: a review.Environmental chemistry letters · 2022Review
- Interaction of chloramphenicol with titin I27 probed using single-molecule force spectroscopy.Journal of biological physics · 2021Article
- Pediatric melanoma-The whole (conflicts of interest) story.International journal of women's dermatology · 2019Review
- Antibiotic Discovery: Where Have We Come from, Where Do We Go?Antibiotics (Basel, Switzerland) · 2019Review
- The Effect of Bacteriophage Preparations on Intracellular Killing of Bacteria by Phagocytes.Journal of immunology research · 2015Article
- Chloramphenicol and acute esophagitis in the emergency department.Journal of emergencies, trauma, and shockArticle
- Aptamer-Based Magnetic Nanoprobe for Quantitative Measurement of Chloramphenicol in Milk through Portable Reader.Journal of medical signals and sensorsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloramphenicol, a broad-spectrum antibiotic, is rarely used in the United States due to its well-described adverse effects. Because of its limited use, many clinicians are unfamiliar with its indications, spectrum of activity, and potential adverse drug effects. We describe a 12-year-old patient who presented after two craniotomies for a persistent brain abscess complicated by long-term chloramphenicol administration. Findings for this patient were consistent with many of the adverse drug effects associated with chloramphenicol, including elevated chloramphenicol serum concentrations, anemia, thrombocytopenia, reticulocytopenia, and severe metabolic acidosis. Rare manifestations of chloramphenicol toxicity that developed in this patient included neutropenia, visual field changes, and peripheral neuropathy. Chloramphenicol administration was discontinued, and hemodialysis was initiated for severe metabolic acidosis. The patient recovered with severe visual field deficits. Although chloramphenicol is rarely indicated, it remains an effective antibiotic. Healthcare providers should become familiar with the pharmacology, toxicology, and monitoring parameters for appropriate use of this antibiotic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.