ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2012
Heparin-induced thrombocytopenia in the pediatric population: a review of current literature.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Drug-Related Side Effects and Contributing Risk Factors in Children With Congenital Heart Disease: A Cross-Sectional Study.Health science reports · 2025Article
- Use of anticoagulants in children: a cross-sectional study at Albert Royer Children Hospital and Cardio-Pediatric Surgery Center of Fann University Hospital in Dakar, Senegal.The Pan African medical journal · 2025Article
- Continuous kidney replacement therapy in critically ill children: heparin vs citrate.Pediatric research · 2024Article
- A retrospective analysis of the frequency of heparin-induced thrombocytopenia in the intensive care unit at a tertiary care center in Riyadh, Saudi Arabia.American journal of blood research · 2023Article
- Heparin Induced Thrombocytopenia - Pathophysiology, Diagnosis and Treatment: A Narrative Review.International journal of general medicine · 2023Review
- Thrombosis Prevention and Anticoagulation Management in the Pediatric Patient with Congenital Heart Disease.Cardiology and therapy · 2021Review
- Neonatal Venous Thromboembolism.Frontiers in pediatrics · 2017Review
- Perioperative care in an adolescent patient with heparin-induced thrombocytopenia for placement of a cardiac assist device and heart transplantation: case report and literature review.International medical case reports journal · 2017Article
- Immune pathogenesis of heparin-induced thrombocytopenia.Thrombosis and haemostasis · 2016Review
- Pediatric heparin-induced thrombocytopenia: prevalence, thrombotic risk, and application of the 4Ts scoring system.The Journal of pediatrics · 2015Article
- Update on argatroban for the prophylaxis and treatment of heparin-induced thrombocytopenia type II.Journal of blood medicine · 2014Review
- Acute stent thrombosis and heparin induced thrombocytopenia: another manifestation of kounis syndrome?Korean circulation journal · 2013Article
- Kounis syndrome: a monster for the atopic patient.Cardiovascular diagnosis and therapy · 2013Article
- Why is the platelet count low: should I be concerned about heparin-induced thrombocytopenia?The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2012Article
- Ranitidine-induced Thrombocytopenia in a Neonate - A Case Report and Review of Literature.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heparin-induced thrombocytopenia is a rare and serious reaction to unfractionated heparin and low-molecular-weight heparins in children. Quick recognition, discontinuation of heparin, and subsequent treatment with an alternative anticoagulant are essential steps to prevent serious complications such as thrombus and limb amputation. The purpose of this review is to describe the clinical features of heparin-induced thrombocytopenia in children and to summarize the data available for its management. This paper summarizes data and relates the use of direct thrombin inhibitors with clinical outcomes. A literature search was conducted with Ovid, using the key terms argatroban, bivalirudin, hirulog, danaparoid, lepirudin, direct thrombin inhibitor, heparin-induced thrombocytopenia, thrombosis, warfarin, and fondaparinux. Articles were excluded if they were classified as editorials, review articles, or conference abstracts or if they involved patients 18 years of age or older or described disease states not related to thrombosis. Nineteen articles containing 33 case reports were identified and evaluated for this review. Of the 33 cases, 14, 10, 4, and 2 cases described the use of lepirudin, danaparoid, argatroban, and bivalirudin, respectively. Two cases did not report the type of anticoagulant used, and 1 case used aspirin. The most commonly reported complication was bleeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.