ReviewJournal of biomedicine & biotechnology2012
Ectonucleotidases in tumor cells and tumor-associated immune cells: an overview.
Review in Journal of biomedicine & biotechnology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Is the regulation by miRNAs of NTPDase1 and ecto-5'-nucleotidase genes involved with the different profiles of breast cancer subtypes?Purinergic signalling · 2022Article
- P2YMolecules (Basel, Switzerland) · 2021Review
- Ectonucleotidases in Inflammation, Immunity, and Cancer.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Characterization of the Endometrial MSC Marker Ectonucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2/CD39L1) in Low- and High-Grade Endometrial Carcinomas: Loss of Stromal Expression in the Invasive Phenotypes.Journal of personalized medicine · 2021Article
- P2X7 receptors and glioma cells.Purinergic signalling · 2020Article
- Role of the P2X7 receptor inOncotarget · 2019Article
- Circulating and tumor-infiltrating myeloid-derived suppressor cells in cervical carcinoma patients.Oncology letters · 2018Article
- Review
- Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors.Frontiers in pharmacology · 2017Article
- Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells.Molecular cancer · 2015Article
- Article
- NTPDase3 and ecto-5'-nucleotidase/CD73 are differentially expressed during mouse bladder cancer progression.Purinergic signalling · 2014Article
- Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1.Cell death and differentiation · 2014Article
- Cytotoxicity and enzyme inhibition studies of polyoxometalates and their chitosan nanoassemblies.Toxicology reports · 2014Article
- Circulating and tumor-infiltrating myeloid-derived suppressor cells in patients with colorectal carcinoma.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence points out that genetic alteration does not guarantee the development of a tumor and indicates that complex interactions of tumor cells with the microenvironment are fundamental to tumorigenesis. Among the pathological alterations that give tumor cells invasive potential, disruption of inflammatory response and the purinergic signaling are emerging as an important component of cancer progression. Nucleotide/nucleoside receptor-mediated cell communication is orchestrated by ectonucleotidases, which efficiently hydrolyze ATP, ADP, and AMP to adenosine. ATP can act as danger signaling whereas adenosine, acts as a negative feedback mechanism to limit inflammation. Many tumors exhibit alterations in ATP-metabolizing enzymes, which may contribute to the pathological events observed in solid cancer. In this paper, the main changes occurring in the expression and activity of ectonucleotidases in tumor cells as well as in tumor-associated immune cells are discussed. Furthermore, we focus on the understanding of the purinergic signaling primarily as exemplified by research done by the group on gliomas.
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