ArticleJournal of medical genetics2012
Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population.
Article in Journal of medical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 59 citations in OpenAlex.
- Genetic and Environmental Influences on Singing Self-Evaluation and its Relationship with Singing Ability: An Australian Twin Study.Behavior genetics · 2026Article
- Gene Co-Expression Analysis of Multiple Brain Tissues Reveals Correlation of FAM222A Expression with Multiple Alzheimer's Disease-Related Genes.Journal of Alzheimer's disease : JAD · 2024Article
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- Genome-wide association study of musical beat synchronization demonstrates high polygenicity.Nature human behaviour · 2022Article
- Genetic factors and shared environment contribute equally to objective singing ability.iScience · 2022Article
- Auditory affective processing, musicality, and the development of misophonic reactions.Frontiers in neuroscience · 2022Review
- Music Aptitude, Training, and Cognitive Transfer: A Mini-Review.Frontiers in psychology · 2022Review
- Review
- Genetically related singers-acoustic feature analysis and impact on singer identification.Journal of applied genetics · 2021Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- Music-listening regulates human microRNA expression.Epigenetics · 2021Article
- How far musicality and perfect pitch are derived from genetic factors?Journal of applied genetics · 2020Review
- Article
- Vocal Parameters of Speech and Singing Covary and Are Related to Vocal Attractiveness, Body Measures, and Sociosexuality: A Cross-Cultural Study.Frontiers in psychology · 2019Article
- Inherent auditory skills rather than formal music training shape the neural encoding of speech.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Factors affecting pitch discrimination performance in a cohort of extensively phenotyped healthy volunteers.Scientific reports · 2017Article
- Convergent evidence for the molecular basis of musical traits.Scientific reports · 2016Review
- Article
- Defining the biological bases of individual differences in musicality.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions.Molecular psychiatry · 2015Article
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMusical abilities such as recognising music and singing performance serve as means for communication and are instruments in sexual selection. Specific regions of the brain have been found to be activated by musical stimuli, but these have rarely been extended to the discovery of genes and molecules associated with musical ability.
methodsA total of 1008 individuals from 73 families were enrolled and a pitch-production accuracy test was applied to determine musical ability. To identify genetic loci and variants that contribute to musical ability, we conducted family-based linkage and association analyses, and incorporated the results with data from exome sequencing and array comparative genomic hybridisation analyses.
resultsWe found significant evidence of linkage at 4q23 with the nearest marker D4S2986 (LOD=3.1), whose supporting interval overlaps a previous study in Finnish families, and identified an intergenic single nucleotide polymorphism (SNP) (rs1251078, p = 8.4 × 10(-17)) near UGT8, a gene highly expressed in the central nervous system and known to act in brain organisation. In addition, a non-synonymous SNP in UGT8 was revealed to be highly associated with musical ability (rs4148254, p = 8.0 × 10(-17)), and a 6.2 kb copy number loss near UGT8 showed a plausible association with musical ability (p = 2.9 × 10(-6)).
conclusionsThis study provides new insight into the genetics of musical ability, exemplifying a methodology to assign functional significance to synonymous and non-coding alleles by integrating multiple experimental methods.
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