ArticleThe Journal of clinical endocrinology and metabolism2013
Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes.
Article in The Journal of clinical endocrinology and metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease.The Journal of clinical endocrinology and metabolism · 2024Pooled it
- Immune Cell-specific Genetic Regulation in Graves' Disease: An Integrative Mendelian Randomization Study.Endocrine, metabolic & immune disorders drug targets · 2026Article
- STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan.Gene reports · 2024Article
- ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery.Acta pharmacologica Sinica · 2023Review
- Review
- Article
- Molecular Mechanisms of ARID5B-Mediated Genetic Susceptibility to Acute Lymphoblastic Leukemia.Journal of the National Cancer Institute · 2022Article
- A U-shaped association between serum albumin with total triiodothyronine in adults.Journal of clinical laboratory analysis · 2022Article
- Identification of New Rare Variants Associated With Familial Autoimmune Thyroid Diseases by Deep Sequencing of Linked Loci.The Journal of clinical endocrinology and metabolism · 2021Article
- Toll-Like Receptors Gene Polymorphisms in Autoimmune Disease.Frontiers in immunology · 2021Review
- Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Interaction of Genetic Variations inThyroid : official journal of the American Thyroid Association · 2019Article
- Insulin-like Growth Factor-I Receptor and Thyroid-Associated Ophthalmopathy.Endocrine reviews · 2019Review
- CD40 Signaling in Graves Disease Is Mediated Through Canonical and Noncanonical Thyroidal Nuclear Factor κB Activation.Endocrinology · 2017Article
- Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease.Frontiers in endocrinology · 2017Review
- Dissecting the Genetic Susceptibility to Graves' Disease in a Cohort of Patients of Italian Origin.Frontiers in endocrinology · 2016Article
- Immunogenetics of autoimmune thyroid diseases: A comprehensive review.Journal of autoimmunity · 2015Review
- Role of genetic and non-genetic factors in the etiology of Graves' disease.Journal of endocrinological investigation · 2015Review
- Article
- Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
contextGenetic factors play a major role in the etiology of autoimmune thyroid disease (AITD) including Graves' disease (GD) and Hashimoto's thyroiditis (HT). We have previously identified three loci on chromosomes 10q, 12q, and 14q that showed strong linkage with AITD, HT, and GD, respectively.
objectivesThe objective of the study was to identify the AITD susceptibility genes at the 10q, 12q, and 14q loci. DESIGN AND
participantsThree hundred forty North American Caucasian AITD patients and 183 healthy controls were studied. The 10q, 12q, and 14q loci were fine mapped by genotyping densely spaced single-nucleotide polymorphisms (SNPs) using the Illumina GoldenGate genotyping platform. Case control association analyses were performed using the UNPHASED computer package. Associated SNPs were reanalyzed in a replication set consisting of 238 AITD patients and 276 controls.
resultsFine mapping of the AITD locus, 10q, showed replicated association of the AITD phenotype (both GD and HT) with SNP rs6479778. This SNP was located within the ARID5B gene recently reported to be associated with rheumatoid arthritis and GD in Japanese. Fine mapping of the GD locus, 14q, revealed replicated association of the GD phenotype with two markers, rs12147587 and rs2284720, located within the NRXN3 and TSHR genes, respectively.
conclusionsFine mapping of three linked loci identified novel susceptibility genes for AITD. The discoveries of new AITD susceptibility genes will engender a new understanding of AITD etiology.
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