ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2013
Adaptive radiation-induced epigenetic alterations mitigated by antioxidants.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- Radiation-Responsive Promoters: Molecular Mechanisms, Screening Strategies, and Translational Applications as Radiation Biomarkers.Current issues in molecular biology · 2026Review
- Intergenerational and organ-specific alterations in mitochondrial DNA copy number following preconception irradiation.Redox biology · 2026Article
- Epigenetics, human imprintome, and chronic diseases.Essays in biochemistry · 2025Review
- Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols.Viruses · 2025Article
- Environmental epigenomics and the human imprintome.Environmental epigenetics · 2025Article
- Low-dose radiation research insights in experimental animals: A gateway to therapeutic implications.Veterinary world · 2024Review
- Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols.bioRxiv : the preprint server for biology · 2024Article
- Grandchildren's Longevity and Their Grandfathers' POW Trauma in the U.S. Civil War.Demography · 2024Article
- Overweight grandsons and grandfathers' starvation exposure.Journal of health economics · 2023Article
- Evaluation of Changes in Some Functional Properties of Human Mesenchymal Stromal Cells Induced by Low Doses of Ionizing Radiation.International journal of molecular sciences · 2023Article
- Epigenetics and the Exposome: DNA Methylation as a Proxy for Health Impacts of Prenatal Environmental Exposures.Exposome · 2023Article
- Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol.International journal of molecular sciences · 2022Review
- Differential molecular response in mice and human thymocytes exposed to a combined-dose radiation regime.Scientific reports · 2022Article
- Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts.International journal of molecular sciences · 2021Review
- Variably methylated retrotransposons are refractory to a range of environmental perturbations.Nature genetics · 2021Article
- Effects of Chronic Low-Dose Internal Radiation on Immune-Stimulatory Responses in Mice.International journal of molecular sciences · 2021Article
- The epigenetic and morphogenetic effects of molecular oxygen and its derived reactive species in development.Free radical biology & medicine · 2021Article
- Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant.Cell reports · 2020Article
- An overview on recentAsian journal of pharmaceutical sciences · 2020Review
- Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Humans are exposed to low-dose ionizing radiation (LDIR) from a number of environmental and medical sources. In addition to inducing genetic mutations, there is concern that LDIR may also alter the epigenome. Such heritable effects early in life can either be positively adaptive or result in the enhanced formation of diseases, including cancer, diabetes, and obesity. Herein, we show that LDIR significantly increased DNA methylation at the viable yellow agouti (A(vy)) locus in a sex-specific manner (P=0.004). Average DNA methylation was significantly increased in male offspring exposed to doses between 0.7 and 7.6 cGy, with maximum effects at 1.4 and 3.0 cGy (P<0.01). Offspring coat color was concomitantly shifted toward pseudoagouti (P<0.01). Maternal dietary antioxidant supplementation mitigated both the DNA methylation changes and coat color shift in the irradiated offspring. Thus, LDIR exposure during gestation elicits epigenetic alterations that lead to positive adaptive phenotypic changes that are negated with antioxidants, indicating they are mediated in part by oxidative stress. These findings provide evidence that in the isogenic A(vy) mouse model, epigenetic alterations resulting from LDIR play a role in radiation hormesis, bringing into question the assumption that every dose of radiation is harmful.
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