ArticleJournal of biomedical optics2012
In vivo validation of a bimodal technique combining time-resolved fluorescence spectroscopy and ultrasonic backscatter microscopy for diagnosis of oral carcinoma.
Article in Journal of biomedical optics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- A systematic review of ultrasound biomicroscopy use in pediatric ophthalmology.Eye (London, England) · 2021Pooled it
- Label-free fluorescence lifetime imaging can distinguish cancer from healthy tissue in spontaneously occurring canine oral tumors.Scientific reports · 2026Article
- Dual-modal Photoacoustic and Ultrasound Imaging: from preclinical to clinical applications.Frontiers in photonics · 2024Article
- First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence.Journal of biomedical optics · 2022Article
- Optical Biopsy of the Upper GI Tract Using Fluorescence Lifetime and Spectra.Frontiers in physiology · 2020Article
- Objective Detection of Oral Carcinoma with Multispectral Fluorescence Lifetime Imaging In Vivo.Photochemistry and photobiology · 2016Article
- A novel multimodal optical imaging system for early detection of oral cancer.Oral surgery, oral medicine, oral pathology and oral radiology · 2016Article
- Handheld multispectral fluorescence lifetime imaging system for in vivo applications.Biomedical optics express · 2014Article
- Ultrasound backscatter microscopy for imaging of oral carcinoma.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2013Article
- Endoscopic fluorescence lifetime imaging for in vivo intraoperative diagnosis of oral carcinoma.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2013Article
- Fluorescence lifetime imaging and reflectance confocal microscopy for multiscale imaging of oral precancer.Journal of biomedical optics · 2013Article
- Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Tissue diagnostic features generated by a bimodal technique integrating scanning time-resolved fluorescence spectroscopy (TRFS) and ultrasonic backscatter microscopy (UBM) are investigated in an in vivo hamster oral carcinoma model. Tissue fluorescence is excited by a pulsed nitrogen laser and spectrally and temporally resolved using a set of filters/dichroic mirrors and a fast digitizer, respectively. A 41-MHz focused transducer (37-μm axial, 65-μm lateral resolution) is used for UBM scanning. Representative lesions of the different stages of carcinogenesis show that fluorescence characteristics complement ultrasonic features, and both correlate with histological findings. These results demonstrate that TRFS-UBM provide a wealth of co-registered, complementary data concerning tissue composition and structure as it relates to disease status. The direct co-registration of the TRFS data (sensitive to surface molecular changes) with the UBM data (sensitive to cross-sectional structural changes and depth of tumor invasion) is expected to play an important role in pre-operative diagnosis and intra-operative determination of tumor margins.
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Registered trials
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