ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2013
Recent emergence of the wheat Lr34 multi-pathogen resistance: insights from haplotype analysis in wheat, rice, sorghum and Aegilops tauschii.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Superior haplotypes for transforming crop breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Review
- Integrative evolutionary and structural modeling of leaf rust resistance genes in wheat (Frontiers in plant science · 2026Article
- CRISPR-Cas9 based editing of the susceptibility allele TaLr34 enhances leaf rust resistance in bread wheat without yield penalty.Functional & integrative genomics · 2025Article
- Searching for genes determining the APR phenotype in rye.BMC plant biology · 2025Article
- Review
- Lr34/Yr18/Sr57/Pm38 confers broad-spectrum resistance to fungal diseases via sinapyl alcohol transport for cell wall lignification in wheat.Plant communications · 2024Article
- ATP-binding cassette transporter TaABCG2 contributes to Fusarium head blight resistance by mediating salicylic acid transport in wheat.Molecular plant pathology · 2024Article
- Exploring the Frontier of Wheat Rust Resistance: Latest Approaches, Mechanisms, and Novel Insights.Plants (Basel, Switzerland) · 2024Review
- Breeding for durable resistance against biotrophic fungal pathogens using transgenes from wheat.Molecular breeding : new strategies in plant improvement · 2024Article
- Variations in exons 11 and 12 of the multi-pest resistance wheat geneFrontiers in plant science · 2022Article
- Genomic Approaches to Identify Molecular Bases of Crop Resistance to Diseases and to Develop Future Breeding Strategies.International journal of molecular sciences · 2021Review
- Comparative Transcriptome Analysis of Wheat Lines in the Field Reveals Multiple Essential Biochemical Pathways Suppressed by Obligate Pathogens.Frontiers in plant science · 2021Article
- A large-scale genomic association analysis identifies the candidate causal genes conferring stripe rust resistance under multiple field environments.Plant biotechnology journal · 2021Article
- Development and deployment of KASP markers for multiple alleles of Lr34 in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Distribution and Nucleotide Diversity ofPathogens (Basel, Switzerland) · 2020Article
- Genome-Wide Association Studies in Diverse Spring Wheat Panel for Stripe, Stem, and Leaf Rust Resistance.Frontiers in plant science · 2020Article
- Abscisic acid is a substrate of the ABC transporter encoded by the durable wheat disease resistance gene Lr34.The New phytologist · 2019Article
- Filling the Gap: Functional Clustering of ABC Proteins for the Investigation of Hormonal TransportFrontiers in plant science · 2019Review
- Transcriptomic Analysis Reveal the Molecular Mechanisms of Wheat Higher-Temperature Seedling-Plant Resistance toFrontiers in plant science · 2018Article
- Pathogen-inducible Ta-Lr34res expression in heterologous barley confers disease resistance without negative pleiotropic effects.Plant biotechnology journal · 2018Article
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Authors and funding
7 authors.
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Abstract
Spontaneous sequence changes and the selection of beneficial mutations are driving forces of gene diversification and key factors of evolution. In highly dynamic co-evolutionary processes such as plant-pathogen interactions, the plant's ability to rapidly adapt to newly emerging pathogens is paramount. The hexaploid wheat gene Lr34, which encodes an ATP-binding cassette (ABC) transporter, confers durable field resistance against four fungal diseases. Despite its extensive use in breeding and agriculture, no increase in virulence towards Lr34 has been described over the last century. The wheat genepool contains two predominant Lr34 alleles of which only one confers disease resistance. The two alleles, located on chromosome 7DS, differ by only two exon-polymorphisms. Putatively functional homoeologs and orthologs of Lr34 are found on the B-genome of wheat and in rice and sorghum, but not in maize, barley and Brachypodium. In this study we present a detailed haplotype analysis of homoeologous and orthologous Lr34 genes in genetically and geographically diverse selections of wheat, rice and sorghum accessions. We found that the resistant Lr34 haplotype is unique to the wheat D-genome and is not found in the B-genome of wheat or in rice and sorghum. Furthermore, we only found the susceptible Lr34 allele in a set of 252 Ae. tauschii genotypes, the progenitor of the wheat D-genome. These data provide compelling evidence that the Lr34 multi-pathogen resistance is the result of recent gene diversification occurring after the formation of hexaploid wheat about 8,000 years ago.
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