ArticleArteriosclerosis, thrombosis, and vascular biology2013
Transglutaminase inhibitors attenuate vascular calcification in a preclinical model.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Warfarin-Induced Developmental Toxicity: Insights into Embryogenesis, Teratogenicity, and Molecular Pathways.Journal of developmental biology · 2026Review
- Decoding vascular calcification: mechanistic insights and translational strategies.Cellular and molecular life sciences : CMLS · 2026Review
- Mechanisms of Cardiovascular Calcification and Experimental Models: Impact of Vitamin K Antagonists.Journal of clinical medicine · 2024Review
- Warfarin-Induced Calcification: Potential Prevention and Treatment Strategies.Reviews in cardiovascular medicine · 2022Review
- Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis.Nature aging · 2021Article
- The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification.Stem cells international · 2019Review
- Natural and non-natural antioxidative compounds: potential candidates for treatment of vascular calcification.Cell death discovery · 2019Review
- Transglutaminase 2 in human diseases.BioMedicine · 2017Article
- A single gene connects stiffness in glaucoma and the vascular system.Experimental eye research · 2017Review
- Effects of dietary quercetin on female fertility in mice: implication of transglutaminase 2.Reproduction, fertility, and development · 2016Article
- Wnt16 attenuates TGFβ-induced chondrogenic transformation in vascular smooth muscle.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Two cases of warfarin-induced tracheobronchial calcification after Fontan surgery.Pediatric cardiology · 2014Article
- Inflammatory, metabolic, and genetic mechanisms of vascular calcification.Arteriosclerosis, thrombosis, and vascular biology · 2014Review
- The obligatory role of the actin cytoskeleton on inward remodeling induced by dithiothreitol activation of endogenous transglutaminase in isolated arterioles.American journal of physiology. Heart and circulatory physiology · 2014Article
- Transglutaminase 2 promotes PDGF-mediated activation of PDGFR/Akt1 and β-catenin signaling in vascular smooth muscle cells and supports neointima formation.Journal of vascular research · 2014Article
- Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin.The Journal of biological chemistry · 2013Article
- Attenuation of chondrogenic transformation in vascular smooth muscle by dietary quercetin in the MGP-deficient mouse model.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn vitro, transglutaminase-2 (TG2)-mediated activation of the β-catenin signaling pathway is central in warfarin-induced calcification, warranting inquiry into the importance of this signaling axis as a target for preventive therapy of vascular calcification in vivo. METHODS AND
resultsThe adverse effects of warfarin-induced elastocalcinosis in a rat model include calcification of the aortic media, loss of the cellular component in the vessel wall, and isolated systolic hypertension, associated with accumulation and activation of TG2 and activation of β-catenin signaling. These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit β-catenin signaling. Our study also uncovers a previously uncharacterized ability of quercetin to inhibit TG2. Quercetin reversed the warfarin-induced increase in systolic pressure, underlying the functional consequence of this treatment. Molecular analysis shows that quercetin diet stabilizes the phenotype of smooth muscle and prevents its transformation into osteoblastic cells.
conclusionsInhibition of the TG2/β-catenin signaling axis seems to prevent warfarin-induced elastocalcinosis and to control isolated systolic hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.