SynthesisChest2013
Response of chronic cough to acid-suppressive therapy in patients with gastroesophageal reflux disease.
Synthesis in Chest, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 5 syntheses or guidelines pooled it, 166 citations in OpenAlex.
- Diagnosis and Treatment of Adult Patients with Cough.Respiration; international review of thoracic diseases · 2025Guideline
- Systematic review and meta-analysis: proton pump inhibitors slightly decrease the severity of chronic cough.Scientific reports · 2024Pooled it
- Guidelines on optimizing the use of proton pump inhibitors: PPI stewardship.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Guideline
- Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report.Chest · 2016Guideline
- Tools for assessing outcomes in studies of chronic cough: CHEST guideline and expert panel report.Chest · 2015Guideline
- Trial
- Efficacy of a high-dose proton pump inhibitor in patients with gastroesophageal reflux disease: a single center, randomized, open-label trial.BMC gastroenterology · 2020Trial
- Unravelling the Links Between Gastroesophageal Reflux and Lung Disease: New Insights.Digestive diseases and sciences · 2026Review
- Diagnostic and Management Approach to Reflux-Related Cough.Gastroenterology & hepatology · 2026Article
- Effectiveness of transoral endoscopic fundoplication with or without hiatal hernia repair in patients with gerd and chronic cough.Surgical endoscopy · 2025Article
- How Will a Treatable Traits Approach Reshape Clinical Practice in Chronic Cough?Allergy, asthma & immunology research · 2025Review
- Potassium-competitive Acid Blockers for Treatment of Extraesophageal Symptoms and Signs.Journal of neurogastroenterology and motility · 2025Review
- Patients Presenting With Reflux Symptoms - Whom to Test and Whom to Treat?The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- Article
- A survey of UK respiratory specialists' opinion on the management of chronic cough.ERJ open research · 2024Article
- How to diagnose GERC more effectively: reflections on post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance.BMC pulmonary medicine · 2024Article
- Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor: A Pilot Study on Comparable Efficacy in the Treatment of Gastroesophageal Reflux-Related Cough.Allergy, asthma & immunology research · 2024Article
- Is empiric proton pump inhibition in patients with symptoms of extraesophageal gastroesophageal reflux justified?BMC gastroenterology · 2023Review
- Causal analysis between gastro-oesophageal reflux disease and obstructive sleep apnoea.ERJ open research · 2023Article
- Improved diagnostic yield of symptom association probability involving only cough for gastroesophageal reflux-induced chronic cough.Journal of thoracic disease · 2023Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEpidemiologic and physiologic studies suggest an association between gastroesophageal reflux disease (GERD) and chronic cough. However, the benefit of antireflux therapy for chronic cough remains unclear, with most relevant trials reporting negative findings. This systematic review aimed to reevaluate the response of chronic cough to antireflux therapy in trials that allowed us to distinguish patients with or without objective evidence of GERD.
methodsPubMed and Embase systematic searches identified clinical trials reporting cough response to antireflux therapy. Datasets were derived from trials that used pH-metry to characterize patients with chronic cough.
resultsNine randomized controlled trials of varied design that treated patients with acid suppression were identified (eight used proton pump inhibitors [PPIs], one used ranitidine). Datasets from two crossover studies showed that PPIs significantly improved cough relative to placebo, albeit only in the arm receiving placebo fi rst. Therapeutic gain in seven datasets was greater in patients with pathologic esophageal acid exposure (range, 12.5%-35.8%) than in those without (range, 0.0%-8.6%), with no overlap between groups.
conclusionsA therapeutic benefit for acid-suppressive therapy in patients with chronic cough cannot be dismissed. However, evidence suggests that rigorous patient selection is necessary to identify patient populations likely to be responsive, using physiologically timed cough events during reflux testing, minimal patient exclusion because of presumptive alternative diagnoses, and appropriate power to detect a modest therapeutic gain. Only then can we hope to resolve this vexing clinical management problem.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.