ArticleDrug and alcohol dependence2013
Nicotine related brain activity: the influence of smoking history and blood nicotine levels, an exploratory study.
Article in Drug and alcohol dependence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01588561 (Nicotine Related Brain Activity), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels, an Exploratory Study
Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Cholinergic modulation of sensory perception and plasticity.Neuroscience and biobehavioral reviews · 2023Review
- Investigating the neural correlates of smoking: Feasibility and results of combining electronic cigarettes with fMRI.Scientific reports · 2017Article
- Automatized smoking-related action schemata are reflected by reduced fMRI activity in sensorimotor brain regions of smokers.NeuroImage. Clinical · 2017Article
- Laterality of Brain Activation for Risk Factors of Addiction.Current drug abuse reviews · 2016Review
- Sex-specific effects of cigarette mentholation on brain nicotine accumulation and smoking behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Nicotine levels after IV nicotine and cigarette smoking in men.Experimental and clinical psychopharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIn this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI).
methodsphMRI was used to evaluate brain activity in response to 1.5 mg/70 kg intravenous nicotine or saline. The nicotine and saline were administered on different visits. The time courses of individual subjects' nicotine levels were used as regressors to assess neural activity relating to the infusions. The influence of smoking history and physiological measures on the response to nicotine were also investigated.
resultsGreater lifetime exposure to cigarette smoking was significantly correlated with higher peak serum nicotine levels. PhMRI analysis of the differential response of nicotine compared to the saline condition showed distinctive activation patterns when analyzed with the (a) nicotine time course, (b) nicotine time course controlling for smoking history (pack years), and (c) pack years controlling for nicotine.
conclusionsThese results suggest that smoking exposure history influences serum nicotine levels and the brain's response to nicotine. Alterations in brain activity may be a result of vascular and neuro-adaptations involved in drug exposure and addiction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.