Evidence map›Paper›PMID 23117123›Full record

ReviewTrends in microbiology2013

Synthase-dependent exopolysaccharide secretion in Gram-negative bacteria.

J C Whitney, P L Howell

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 270 citations in OpenAlex.

  1. Article
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  10. Bacteria Under Metal Stress-Molecular Mechanisms of Metal Tolerance.International journal of molecular sciences · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Insights from a Genome-Wide Study ofCurrent issues in molecular biology · 2025
    Article
  15. Article
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  17. Article
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  19. Article
  20. Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J C WhitneyProgram in Molecular Structure and Function, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada.
P L Howell
Canada Research Chairs · CA

Funding

CIHR 13337CIHR 13337-5CIHR 43998CIHR 43998-3
6 · The paper itself

Abstract

The biosynthesis and export of bacterial cell-surface polysaccharides is known to occur through several distinct mechanisms. Recent advances in the biochemistry and structural biology of several proteins in synthase-dependent polysaccharide secretion systems have identified key conserved components of this pathway in Gram-negative bacteria. These components include an inner-membrane-embedded polysaccharide synthase, a periplasmic tetratricopeptide repeat (TPR)-containing scaffold protein, and an outer-membrane β-barrel porin. There is also increasing evidence that many synthase-dependent systems are post-translationally regulated by the bacterial second messenger bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP). Here, we compare these core proteins in the context of the alginate, cellulose, and poly-β-D-N-acetylglucosamine (PNAG) secretion systems.

Indexed as

AlginatesBacterial ProteinsBacterial Secretion Systemsbeta-GlucansCelluloseGlucuronic AcidGram-Negative BacteriaHexuronic AcidsPolysaccharides, BacterialAlginatesBacterial ProteinsBacterial Secretion Systemsbeta-GlucansCelluloseGlucuronic AcidHexuronic Acidspoly-N-acetyl-1-6-glucosaminePolysaccharides, Bacterial

Identifiers

PMID23117123
PMCPMC4113494
OpenAlexW2016965453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.