ArticleAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2012
Association between CYP19A1 genotype and pubertal sagittal jaw growth.
Article in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
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- Polymorphism analysis of myosin 1H (G/A) and P561T (C/A) genes on class I, class II, and class III malocclusion.Journal of orthodontic science · 2022Article
- Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats.International journal of molecular sciences · 2021Article
- Posterior Mandibular Displacement-A Systematic Review Based on Animal Studies.Animals : an open access journal from MDPI · 2021Review
- Masticatory muscle function affects the pathological conditions of dentofacial deformities.The Japanese dental science review · 2020Review
- Linear Predictors of Facial Rotation Pattern in Croatian Subjects with Skeletal Class III Malocclusion.Acta stomatologica Croatica · 2018Article
- Heredity, Genetics and Orthodontics - How Much Has This Research Really Helped?Seminars in orthodontics · 2017Article
- Expressional Analysis of MSX1 (Human) Revealed its Role in Sagittal Jaw Relationship.Journal of clinical and diagnostic research : JCDR · 2017Article
- Classification and characterization of class III malocclusion in Chinese individuals.Head & face medicine · 2016Article
- Genotypic and allelic variability in CYP19A1 among populations of African and European ancestry.PloS one · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionSagittal jaw growth is influenced during puberty by a ratio of androgens and estrogens. The CYP19A1 (formerly CYP19) gene encodes the cytochrome P450 enzyme aromatase (estrogen synthetase), which converts testosterone to estrogen. Genetic variations including single nucleotide polymorphisms might regulate CYP19A1 gene expression or the function of the aromatase protein and thus influence sagittal jaw growth.
methodsThe annual sagittal jaw growth in 92 pubertal orthodontic patients was determined by using pretreatment and posttreatment cephalometric radiographs. Single nucleotide polymorphisms rs2470144 and rs2445761 were genotyped and haplotypes constructed. Associations between genotypes or haplotypes and the annual sagittal growth were estimated by using JMP (version 9.0; SAS Institute, Cary, NC).
resultsTwo single nucleotide polymorphisms were significantly associated with average differences in annual sagittal jaw growth in boys. Haplotype analysis demonstrated that haplotypes T(rs2470144)T(rs2445761) and C(rs2470144)T(rs2445761) had significant effects on annual sagittal maxillary growth and on mandibular growth in boys. No association was found in girls.
conclusionsA quantitative trait locus that influences male pubertal sagittal jaw growth might exist in the CYP19A1 gene, and single nucleotide polymorphisms rs2470144 and rs2445761 might be inside this quantitative trait locus or be linked to it.
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