ArticleBMC developmental biology2012
Heat shock factor-1 intertwines insulin/IGF-1, TGF-β and cGMP signaling to control development and aging.
Article in BMC developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 52 citations in OpenAlex.
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- A nucleolar mechanism suppresses organismal proteostasis by modulating TGFβ/ERK signalling.Nature cell biology · 2025Article
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- Regulatory mechanism of cold-inducible diapause in Caenorhabditis elegans.Nature communications · 2024Article
- Long ant life span is maintained by a unique heat shock factor.Genes & development · 2023Article
- Dauer fate in aPeerJ · 2023Article
- TGF-β pathways in aging and immunity: lessons fromFrontiers in genetics · 2023Review
- HSF1 and Its Role in Huntington's Disease Pathology.Advances in experimental medicine and biology · 2023Review
- Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors inInternational journal of molecular sciences · 2021Article
- Starvation Responses Throughout theGenetics · 2020Review
- Diversified regulation of circadian clock gene expression following whole genome duplication.PLoS genetics · 2020Article
- HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes.International journal of molecular sciences · 2019Article
- Gene structure and expression patterns of Acdaf-1, a TGF-β type I receptor in Ancylostoma caninum.Parasitology research · 2019Article
- The synthesis of diapause-specific molecular chaperones in embryos of Artemia franciscana is determined by the quantity and location of heat shock factor 1 (Hsf1).Cell stress & chaperones · 2019Article
- Functional genomics screen with pooled shRNA library and gene expression profiling with extracts ofPeerJ · 2019Article
- Roles of heat shock factor 1 beyond the heat shock response.Cellular and molecular life sciences : CMLS · 2018Review
- Prediction and characterization of human ageing-related proteins by using machine learning.Scientific reports · 2018Article
- Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans.Cell stress & chaperones · 2018Article
- Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance.Journal of leukocyte biology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTemperature affects virtually all cellular processes. A quick increase in temperature challenges the cells to undergo a heat shock response to maintain cellular homeostasis. Heat shock factor-1 (HSF-1) functions as a major player in this response as it activates the transcription of genes coding for molecular chaperones (also called heat shock proteins) that maintain structural integrity of proteins. However, the mechanisms by which HSF-1 adjusts fundamental cellular processes such as growth, proliferation, differentiation and aging to the ambient temperature remain largely unknown.
resultsWe demonstrate here that in Caenorhabditis elegans HSF-1 represses the expression of daf-7 encoding a TGF-β (transforming growth factor-beta) ligand, to induce young larvae to enter the dauer stage, a developmentally arrested, non-feeding, highly stress-resistant, long-lived larval form triggered by crowding and starvation. Under favorable conditions, HSF-1 is inhibited by crowding pheromone-sensitive guanylate cyclase/cGMP (cyclic guanosine monophosphate) and systemic nutrient-sensing insulin/IGF-1 (insulin-like growth factor-1) signaling; loss of HSF-1 activity allows DAF-7 to promote reproductive growth. Thus, HSF-1 interconnects the insulin/IGF-1, TGF-β and cGMP neuroendocrine systems to control development and longevity in response to diverse environmental stimuli. Furthermore, HSF-1 upregulates another TGF-β pathway-interacting gene, daf-9/cytochrome P450, thereby fine-tuning the decision between normal growth and dauer formation.
conclusionTogether, these results provide mechanistic insight into how temperature, nutrient availability and population density coordinately influence development, lifespan, behavior and stress response through HSF-1.
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