ArticleThe EMBO journal1990
An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 61 citations in OpenAlex.
- Inferring gene expression from cell-free DNA fragmentation profiles.Nature biotechnology · 2022Article
- LMO2 at 25 years: a paradigm of chromosomal translocation proteins.Open biology · 2015Review
- Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia.Leukemia · 2013Article
- Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Islet expression of Rhombotin and Isl-1 suggests cell type specific exposure of LIM-domain epitopes.Endocrine · 1995Article
- Development expression of Hox11 and specification of splenic cell fate.The American journal of pathology · 1995Article
- Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.The EMBO journal · 1995Article
- The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- The mouse homolog of the rhombotin (Ttg-1) gene maps on chromosome 7 distal to the beta-globin (Hbb) locus.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.The Journal of cell biology · 1992Article
- Differential splicing creates a diversity of transcripts from a neurospecific developmentally regulated gene encoding a protein with new zinc-finger motifs.Nucleic acids research · 1992Article
- Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma.Molecular and cellular biology · 1992Article
- An analysis of vertebrate mRNA sequences: intimations of translational control.The Journal of cell biology · 1991Review
- The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- A simple technique for generating probes for RNA in situ hybridization: an adjunct to genome mapping exemplified by the RAG-1/RAG-2 gene cluster.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously identified a putative T cell oncogene on chromosome 11 near a translocation t(11;14)(p15;q11) in a human T cell tumour. The gene is transcribed from distinct promoters which have unrelated sequences, which occur within close but distinct methylation-free islands and which allow cell specific production of mRNA. The alternative first exons each contain a protein initiation codon from which two species of protein can be made, differing by only a single amino acid. The protein sequence is highly conserved between man and mouse (98%) and the same single codon difference between alternative first exons is also conserved. This is, therefore, a new form of eukaryotic gene organization from which similar proteins can be made from distinct mRNA species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.