ArticleThe EMBO journal1990
The regulation of proenkephalin expression in a distinct population of glial cells.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 107 citations in OpenAlex.
- Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain.Cell transplantation · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Acute and chronic mu opioids differentially regulate thrombospondins 1 and 2 isoforms in astrocytes.ACS chemical neuroscience · 2014Article
- Opiate drug use and the pathophysiology of neuroAIDS.Current HIV research · 2012Review
- Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways.Journal of neurochemistry · 2009Article
- Trafficking and fusion of neuropeptide Y-containing dense-core granules in astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Glial expression of the proenkephalin gene in slice cultures of the subventricular zone.Journal of molecular neuroscience : MN · 1998Article
- Article
- kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.Brain research · 1996Article
- Regulation of the expression of the proenkephalin gene in cultured meningeal fibroblasts: opposite effects of alpha 1- and beta 2-adrenoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 1996Article
- FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.The EMBO journal · 1996Article
- mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism.Brain research · 1996Article
- Proenkephalin is a nuclear protein responsive to growth arrest and differentiation signals.The Journal of cell biology · 1995Article
- The transcriptional regulation of the preproenkephalin gene.The Biochemical journal · 1995Review
- Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element.Molecular and cellular biology · 1994Article
- Molecular profile of reactive astrocytes--implications for their role in neurologic disease.Neuroscience · 1993Review
- Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.Neurochemical research · 1992Article
- Expression of prepro-enkephalin in human articular chondrocytes is linked to cell proliferation.The EMBO journal · 1992Article
- Morphine alters astrocyte growth in primary cultures of mouse glial cells: evidence for a direct effect of opiates on neural maturation.Brain research. Developmental brain research · 1991Article
- Cellular localization of proenkephalin mRNA and enkephalin peptide products in cultured astrocytes.Brain research · 1990Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The expression of opioid genes was examined in isolated populations of glial cells in primary culture. Northern blot analysis of purified type I astrocytes, oligodendrocytes and mixed oligodendrocyte-type-2-astrocyte lineage cells derived from cerebral cortex demonstrated robust expression of proenkephalin mRNA exclusively in type I astrocytes. The expression of proenkephalin mRNA was stimulated by the beta-adrenergic agonist isoproterenol, and 8-(4-chlorophenyl thio)adenosine 3'-5'-cyclic monophosphate (cpt-cAMP). Both of these compounds regulated a proenkephalin-chloramphenicol acetyltransferase fusion gene transiently transfected into type I astrocytes. HPLC and immunoassay of the cell culture media revealed significant levels of unprocessed proenkephalin secreted by the cell and this secretion was stimulated by isoproterenol and cpt-cAMP. The relatively high levels of proenkephalin expressed suggest that enhanced expression in astrocytes may be important during neural development, in trauma-induced gliosis and in neuroimmune interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.