ArticleThe EMBO journal1990
The predicted amino acid sequence of alpha-internexin is that of a novel neuronal intermediate filament protein.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 127 citations in OpenAlex.
- Review
- Transgenic mouse models of multiple sclerosis.Cellular and molecular life sciences : CMLS · 2010Review
- Article
- Proteome analysis after co-administration of clozapine or haloperidol to MK-801-treated rats.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- Intermediate filaments: a historical perspective.Experimental cell research · 2007Review
- Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Intermediate filament expression in prostate cancer.Cancer metastasis reviews · 1996Review
- The 66-kDa neurofilament protein (NF-66): sequence analysis and evolution.Neurochemical research · 1996Article
- Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons.The Journal of cell biology · 1994Article
- A review of intermediate filament biology and their use in pathologic diagnosis.Molecular biology reports · 1994Review
- Peripherin expression in hippocampal neurons induced by muscle soluble factor(s).The Journal of cell biology · 1993Article
- Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments.The Journal of cell biology · 1993Article
- Neurofilaments are obligate heteropolymers in vivo.The Journal of cell biology · 1993Article
- Rapid identification of proteins.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Cell-specific transcription of the peripherin gene in neuronal cell lines involves a cis-acting element surrounding the TATA box.The EMBO journal · 1992Article
- Schwann cells of the myelin-forming phenotype express neurofilament protein NF-M.The Journal of cell biology · 1992Article
- Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease.The EMBO journal · 1992Article
- Unexpected immunoreactivities of intermediate filament antibodies in human brain and brain tumors.The American journal of pathology · 1991Article
- Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit.The Journal of cell biology · 1990Article
- Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M.The Journal of cell biology · 1990Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Our laboratory recently isolated and began to characterize a 66 kd rat brain cytoskeletal protein, dubbed alpha-internexin for its interactions in vitro with several other cytoskeletal proteins. Although alpha-internexin bore several of the characteristics of intermediate filament (IF) proteins, including the recognition by an antibody reactive with all IF proteins, it did not polymerize into 10 nm filaments under the conditions tested. Here we show that the predicted amino acid sequence of a cDNA encoding alpha-internexin shows the latter to be an IF protein, probably most closely related to the neurofilament proteins. Northern blotting shows that alpha-internexin expression is brain specific, and that rat brain alpha-internexin mRNA levels are maximal prior to birth and decline into adulthood, while the converse is seen for NF-L, the low molecular weight neurofilament subunit, suggesting that these two proteins play different roles in the developing brain.
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