ArticleAllergy, asthma & immunology research2012
Elevated Serum Levels of IL-21 in Kawasaki Disease.
Article in Allergy, asthma & immunology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Interaction of S100A6 Protein with the Four-Helical Cytokines.Biomolecules · 2023Article
- SARS-CoV-2 infection in the context of Kawasaki disease and multisystem inflammatory syndrome in children.Medical microbiology and immunology · 2023Review
- Antibodies and Immunity During Kawasaki Disease.Frontiers in cardiovascular medicine · 2020Review
- Distribution of distinct subsets of circulating T follicular helper cells in Kawasaki disease.BMC pediatrics · 2019Article
- Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease.BMC immunology · 2018Article
- Suppressed plasmablast responses in febrile infants, including children with Kawasaki disease.PloS one · 2018Article
- Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children.Pediatric rheumatology online journal · 2017Observational
- Association of Attention deficit hyperactivity disorder and Kawasaki disease: a nationwide population-based cohort study.Epidemiology and psychiatric sciences · 2016Article
- Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.PloS one · 2014Article
- Interleukin-21 receptor gene polymorphisms in kawasaki disease.Korean circulation journal · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe serum level of immunoglobulin (Ig)E has been reported to be elevated in patients with Kawasaki disease (KD). We investigated whether interleukin (IL)-21, rather than IL-4, could be related to elevated serum levels of IgE in KD.
methodsSera from 48 patients with KD and 12 controls with high fever were collected to determine the level of IgE using an immunoassay system and the levels of IL-4 and IL-21 were determined using enzyme-linked immunosorbent assay kits.
resultsThe median IL-21 level of KD patients was significantly elevated, at 499.5 pg/mL (range: <62.5-1,544 pg/mL), whereas that of controls was <62.5 pg/mL (<62.5-825 pg/mL; P<0.001). The median IL-4 level of KD patients was not elevated (4.0 pg/mL; 2.1-7.6 pg/mL). The median level of total IgE in KD patients was 58.0 IU/mL (5-1,109 IU/mL). No statistically significant correlation was found between IL-21 and total IgE levels (Spearman's R=0.2; P=0.19).
conclusionsPatients with KD have elevated levels of IL-21 in the serum. IL-21 may play a role in the pathogenesis of KD.
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