ArticleFrontiers in physiology2012
Reduction of heart rate by omega-3 fatty acids and the potential underlying mechanisms.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Effect of omega-3 long-chain polyunsaturated fatty acid supplementation on heart rate: a meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2018Pooled it
- Potential Role of Omega-3 Supplementation in Modulating Symptoms and Holter Parameters in Pediatric Inappropriate Sinus Tachycardia.Indian journal of pediatrics · 2026Trial
- Effects of Prenatal DHA Dose on Infant Visual Attention.Developmental psychobiology · 2025Trial
- Omega and heart rate variability in overweight and obese schoolchildren.Pediatric research · 2025Trial
- Omega-3 fatty acids and autonomic function in adolescents with anorexia: A randomized trial.Pediatric research · 2022Trial
- Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial.Scientific reports · 2019Trial
- Fatty Acids and Their Roles in Cardiac Physiology and Pathology: Mechanistic and Interventional Studies.Nutrients · 2026Review
- Six weeks of either EPA-rich or DHA-rich Omega-3 supplementation alters submaximal exercise physiology in endurance trained male amateurs.Frontiers in nutrition · 2025Article
- Omega-3 Fatty Acids and Heart Rhythm, Rate, and Variability in Atrial Fibrillation.Journal of the American Heart Association · 2023Article
- Direct evidence of bradycardic effect of omega-3 fatty acids acting on nucleus ambiguus.Neuroscience letters · 2020Article
- Article
- Lipidomics Reveals the Therapeutic Effects of EtOAc Extract ofFrontiers in pharmacology · 2020Article
- Omega-3 Fatty Acid Supplementation Improves Heart Rate Variability in Obese Children.International journal of pediatrics · 2018Article
- Metabolism and functions of docosahexaenoic acid-containing membrane glycerophospholipids.FEBS letters · 2017Review
- Multiple differences between patients who initiate fish oil supplementation post-myocardial infarction and those who do not: the TRIUMPH Study.Nutrition research (New York, N.Y.) · 2016Article
- Dietary pre-exposure of rats to fish oil does not enhance myocardial efficiency of isolated working hearts or their left ventricular trabeculae.The Journal of physiology · 2014Article
- Cardiac physiology and clinical efficacy of dietary fish oil clarified through cellular mechanisms of omega-3 polyunsaturated fatty acids.European journal of applied physiology · 2014Review
- Dietary supplementation with either saturated or unsaturated fatty acids does not affect the mechanoenergetics of the isolated rat heart.Physiological reports · 2014Article
- Cardioprotective effects of ω -3 PUFAs in chronic kidney disease.BioMed research international · 2013Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An elevated resting heart rate is one of the strongest predictors of cardiovascular mortality and is independently associated with sudden cardiac death (SCD). Agents capable of reducing heart rate without significant side effects are therefore of particular interest for the prevention of SCD. Recent human and animal studies have shown that omega-3 fatty acids can reduce heart rate. Our work has shown that omega-3 fatty acids significantly reduce membrane electrical excitability of the cardiac myocyte by lowering its resting membrane potential and the duration of the refractory period through inhibition of ion channels. We propose that these actions may be the underlying mechanisms for the omega-3 fatty acid-induced reduction of heart rate observed in both humans and animals. The heart rate-lowering capability of omega-3 fatty acids may contribute to their preventive effect against SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.