ArticleFrontiers in behavioral neuroscience2012
The neural substrates of deliberative decision making: contrasting effects of hippocampus lesions on performance and vicarious trial-and-error behavior in a spatial memory task and a visual discrimination task.
Article in Frontiers in behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 38 citations in OpenAlex.
- A novel rat spatial inference task reveals rapid deduction of transitive relationships using schemas and deliberation.Behavioral neuroscience · 2026Article
- A Novel Rat Spatial Inference Task Reveals Rapid Deduction of Transitive Relationships Using Schemas and Deliberation.bioRxiv : the preprint server for biology · 2025Article
- Choice Behaviors and Prefrontal-Hippocampal Coupling Are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Spatiotemporal dynamics of locomotor decisions inbioRxiv : the preprint server for biology · 2024Article
- Deliberative Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders.bioRxiv : the preprint server for biology · 2024Article
- Flexible decision-making is related to strategy learning, vicarious trial and error, and medial prefrontal rhythms during spatial set-shifting.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- An Improved Dyna-Q Algorithm Inspired by the Forward Prediction Mechanism in the Rat Brain for Mobile Robot Path Planning.Biomimetics (Basel, Switzerland) · 2024Article
- Rodent maze studies: from following simple rules to complex map learning.Brain structure & function · 2024Review
- Pausing and reorienting behaviors enhance the performance of a spatial working memory task.Behavioural brain research · 2023Article
- Optogenetic disruption of the prelimbic cortex alters long-term decision strategy but not valuation on a spatial delay discounting task.Neurobiology of learning and memory · 2023Article
- The ventral midline thalamus coordinates prefrontal-hippocampal neural synchrony during vicarious trial and error.Scientific reports · 2022Article
- A Machine Learning Approach for Detecting Vicarious Trial and Error Behaviors.Frontiers in neuroscience · 2021Article
- Learning, memory and consolidation mechanisms for behavioral control in hierarchically organized cortico-basal ganglia systems.Hippocampus · 2020Review
- Article
- A Closer Look at the Hippocampus and Memory.Trends in cognitive sciences · 2017Review
- Hippocampal-cortical contributions to strategic exploration during perceptual discrimination.Hippocampus · 2017Article
- Lasting Adaptations in Social Behavior Produced by Social Disruption and Inhibition of Adult Neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Vicarious trial and error.Nature reviews. Neuroscience · 2016Review
- Adult neurogenesis: beyond learning and memory.Annual review of psychology · 2015Review
- Aging impairs deliberation and behavioral flexibility in inter-temporal choice.Frontiers in aging neuroscience · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vicarious trial-and-errors (VTEs) are back-and-forth movements of the head exhibited by rodents and other animals when faced with a decision. These behaviors have recently been associated with prospective sweeps of hippocampal place cell firing, and thus may reflect a rodent model of deliberative decision-making. The aim of the current study was to test whether the hippocampus is essential for VTEs in a spatial memory task and in a simple visual discrimination (VD) task. We found that lesions of the hippocampus with ibotenic acid produced a significant impairment in the accuracy of choices in a serial spatial reversal (SR) task. In terms of VTEs, whereas sham-lesioned animals engaged in more VTE behavior prior to identifying the location of the reward as opposed to repeated trials after it had been located, the lesioned animals failed to show this difference. In contrast, damage to the hippocampus had no effect on acquisition of a VD or on the VTEs seen in this task. For both lesion and sham-lesion animals, adding an additional choice to the VD increased the number of VTEs and decreased the accuracy of choices. Together, these results suggest that the hippocampus may be specifically involved in VTE behavior during spatial decision making.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.