ArticleCurrent genomics2012
Comparison of models for the collinearity of hox genes in the developmental axes of vertebrates.
Article in Current genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Review
- Hox genes are crucial regulators of periosteal stem cell identity.Development (Cambridge, England) · 2023Article
- Physical Laws Shape Up HOX Gene Collinearity.Journal of developmental biology · 2021Review
- Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells.eLife · 2018Article
- Abnormal Elongations of HOX Gene Clusters May Cause Cancer.Frontiers in cell and developmental biology · 2018Article
- Article
- Hox Gene Collinearity: From A-P Patterning to Radially Symmetric Animals.Current genomics · 2015Article
- Evolutionary constraints favor a biophysical model explaining hox gene collinearity.Current genomics · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox gene clusters are very frequent in many animal genomes and their role in development is pivotal. Particularly in vertebrates, intensive efforts have established several properties of Hox clusters. The collinearity of Hox gene expressions (spatial, temporal and quantitative) is a common feature of the vertebrates. During the last decade, genetic engineering experiments have revealed some important facets of collinearity during limb and trunk development in mice. Two models have been proposed to explain all these properties. On one hand the 'two-phases model' makes use of the molecular regulatory mechanisms acting on the Hox genes. On the other hand, the'biophysical model' is based on the signals transduced inside the cell nucleus and the generation of forces which apply on the cluster and lead to a coordinated activation of Hox genes. The two models differ fundamentally and a critical and detailed comparison is presented. Furthermore, experiments are proposed for which the two models provide divergent predictions. The outcome of these experiments will help to decide which of the two models is valid (if any).
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Registered trials
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