Trial reportSleep2012
Efficacy of eight months of nightly zolpidem: a prospective placebo-controlled study.
Trial report in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01006525 (Abuse Liability Associated With Chronic Hypnotic Use), which is not on this map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Abuse Liability Associated With Chronic Hypnotic Use
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Pooled it
- Effects of mindfulness-based cognitive therapy on older adults with sleep disorders: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Comparative efficacy of lemborexant and other insomnia treatments: a network meta-analysis.Journal of managed care & specialty pharmacy · 2021Pooled it
- Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Guideline
- Effect of Placebo Conditions on Polysomnographic Parameters in Primary Insomnia: A Meta-Analysis.Sleep · 2015Pooled it
- Drug treatment of primary insomnia: a meta-analysis of polysomnographic randomized controlled trials.CNS drugs · 2014Pooled it
- Randomized controlled trial of zolpidem as a pharmacotherapy for cannabis use disorder.Journal of substance use and addiction treatment · 2024Trial
- Trial
- Trial
- Trial
- Hyperarousal in insomnia and hypnotic dose escalation.Sleep medicine · 2016Trial
- Effects of zolpidem alone and in combination with nabilone on cannabis withdrawal and a laboratory model of relapse in cannabis users.Psychopharmacology · 2016Trial
- Gender Differences in the Efficacy and Safety of Chronic Nightly Zolpidem.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Trial
- Low-dose paroxetine (7.5 mg) improves sleep in women with vasomotor symptoms associated with menopause.Menopause (New York, N.Y.) · 2015Trial
- Trial
- Article
- Pharmacological and psychological approaches to insomnia treatment in cardiac patients: a narrative literature review.Frontiers in psychiatry · 2025Review
- Assessing the Risk of Bias in Randomized Clinical Trials With Large Language Models.JAMA network open · 2024Article
- Personalized transcranial alternating current stimulation improves sleep quality: Initial findings.Frontiers in human neuroscience · 2022Article
- Prescription medications for sleep disturbances among midlife women during 2 years of follow-up: a SWAN retrospective cohort study.BMJ open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesTo evaluate the long-term (8 months) efficacy of zolpidem in adults with chronic primary insomnia using polysomnography.
designRandomized, double-blind, placebo-controlled clinical trial.
settingSleep disorders and research center.
participantsHealthy participants (n = 91), ages 23-70, meeting DSM-IV-TR criteria for primary insomnia.
interventionsNightly zolpidem, 10 mg (5 mg for patients > 60 yrs) or placebo 30 minutes before bedtime for 8 months. MEASUREMENTS AND
resultsPolysomnographic sleep parameters and morning subject assessments of sleep on 2 nights in months 1 and 8. Relative to placebo, zolpidem significantly increased overall total sleep time and sleep efficiency, reduced sleep latency and wake after sleep onset when assessed at months 1 and 8. Overall, subjective evaluations of efficacy were not shown among treatment groups.
conclusionsIn adults with primary insomnia, nightly zolpidem administration remained efficacious across 8 months of nightly use. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov Identifier: NCT01006525; Trial Name: Safety and Efficacy of Chronic Hypnotic Use; http://clinicaltrials.gov/ct2/show/NCT01006525.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.