Trial reportSleep2012
Short sleep duration, glucose dysregulation and hormonal regulation of appetite in men and women.
Trial report in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Deprivation and Energy Balance
The SLuMBER Study: The Sleep Lengthening and Metabolic Health, Body Composition, Energy Balance and Cardiovascular Risk Study
Impact of Sleep Restriction on Cardiometabolic Risk Factors in Pre vs Postmenopausal Women
The Effects of a High Protein Breakfast on Appetite and Sleep in Young Adults
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Are Emotional Eating and Other Eating Behaviors the Missing Link in the Relationship between Inadequate Sleep and Obesity? A Systematic Review.Nutrients · 2023Pooled it
- Association between sleep apnea and low bone mass in adults: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Sleep behaviours and associated habits and the progression of pre-diabetes to type 2 diabetes mellitus in adults: A systematic review and meta-analysis.Diabetes & vascular disease researchPooled it
- Chronic Insufficient Sleep in Women Impairs Insulin Sensitivity Independent of Adiposity Changes: Results of a Randomized Trial.Diabetes care · 2024Trial
- Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food.Nutrients · 2023Trial
- Sleep Disturbance and Changes in Energy Intake and Body Composition During Weight Loss in the POUNDS Lost Trial.Diabetes · 2022Trial
- Sleep restriction and testosterone concentrations in young healthy males: randomized controlled studies of acute and chronic short sleep.Sleep health · 2019Trial
- Sleep and meal timing influence food intake and its hormonal regulation in healthy adults with overweight/obesity.European journal of clinical nutrition · 2019Trial
- Influence of sleep restriction on weight loss outcomes associated with caloric restriction.Sleep · 2018Trial
- Pilot study of sleep and meal timing effects, independent of sleep duration and food intake, on insulin sensitivity in healthy individuals.Sleep health · 2018Trial
- Sleep extension is a feasible lifestyle intervention in free-living adults who are habitually short sleepers: a potential strategy for decreasing intake of free sugars? A randomized controlled pilot study.The American journal of clinical nutrition · 2018Trial
- Partial sleep deprivation impacts impulsive action but not impulsive decision-making.Physiology & behavior · 2016Trial
- Fiber and Saturated Fat Are Associated with Sleep Arousals and Slow Wave Sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Trial
- Elevated ghrelin predicts food intake during experimental sleep restriction.Obesity (Silver Spring, Md.) · 2016Trial
- Trial
- Acute Changes in Sleep Duration on Eating Behaviors and Appetite-Regulating Hormones in Overweight/Obese Adults.Behavioral sleep medicine · 2015Trial
- Sex and race differences in caloric intake during sleep restriction in healthy adults.The American journal of clinical nutrition · 2014Trial
- Fasting plasma adropin concentrations correlate with fat consumption in human females.Obesity (Silver Spring, Md.) · 2014Trial
- Experimental sleep curtailment causes wake-dependent increases in 24-h energy expenditure as measured by whole-room indirect calorimetry.The American journal of clinical nutrition · 2013Trial
- Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectiveTo determine the hormonal effects of reducing sleep duration under controlled feeding conditions.
designRandomized, crossover study.
settingInpatient.
participantsTwenty-seven normal weight, 30- to 45-yr-old men and women habitually sleeping 7-9 hr/night.
interventionPARTICIPANTS WERE STUDIED UNDER TWO SLEEP CONDITIONS: short (4 hr in bed) or habitual (9 hr in bed) sleep. A controlled diet was provided for each 4-day study period. MEASUREMENTS AND
resultsFasting blood samples were obtained daily and frequent blood samples were obtained throughout day 4. The main outcomes measures included glucose, insulin, leptin, ghrelin, adiponectin, total glucagon-like peptide 1 (GLP-1) and peptide YY(3-36) (PYY(3-36)) concentrations. Body weights were reduced by 2.2 ± 0.4 lb and 1.7 ± 0.4 lb during the habitual and short sleep phases, respectively (both P < 0.0001). There was no effect of sleep duration on glucose, insulin, and leptin profiles (all P > 0.05). Ghrelin and GLP-1 responses differed by sex. Short sleep increased fasting (P = 0.054) and morning (08:00-12:00) (P = 0.042) total ghrelin in men but not women. The reverse was observed for GLP-1: afternoon levels (12:30-19:00) were lower (P = 0.016) after short sleep compared with habitual sleep in women but not men.
conclusionsThese data suggest that, in the context of negative energy balance, short sleep does not lead to a state of increased insulin resistance, but may predispose to overeating via separate mechanisms in men and women. CLINICAL TRIAL INFORMATION: Trial registration on http://www.clinicaltrials.gov. #NCT00935402.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.