ArticleMolecular biology of the cell2012
Bld10/Cep135 stabilizes basal bodies to resist cilia-generated forces.
Article in Molecular biology of the cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 70 citations in OpenAlex.
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- Structure and assembly of the A-C linker connecting microtubule triplets in centrioles.Science advances · 2025Article
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- Molecular basis promoting centriole triplet microtubule assembly.Nature communications · 2024Article
- Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells.eLife · 2024Article
- CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity.The Journal of cell biology · 2023Article
- Towards understanding centriole elimination.Open biology · 2023Review
- Basal body organization and cell geometry during the cell cycle inMolecular biology of the cell · 2023Article
- CP110 and CEP135 localize near the proximal and distal centrioles of cattle and human spermatozoa.microPublication biology · 2023Article
- Basal bodies bend in response to ciliary forces.Molecular biology of the cell · 2022Article
- Bld10p/Cep135 determines the number of triplets in the centriole independently of the cartwheel.The EMBO journal · 2022Article
- Ciliate cortical organization and dynamics for cell motility: Comparing ciliates and vertebrates.The Journal of eukaryotic microbiology · 2022Review
- A modified TurboID approach identifies tissue-specific centriolar components in C. elegans.PLoS genetics · 2022Article
- UsingGenes · 2021Review
- Plastic cell morphology changes during dispersal.iScience · 2021Article
- Architecture of the centriole cartwheel-containing region revealed by cryo-electron tomography.The EMBO journal · 2020Article
- WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.eLife · 2020Article
- Sas4 links basal bodies to cell division via Hippo signaling.The Journal of cell biology · 2020Article
- With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making.Cells · 2020Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Basal bodies nucleate, anchor, and organize cilia. As the anchor for motile cilia, basal bodies must be resistant to the forces directed toward the cell as a consequence of ciliary beating. The molecules and generalized mechanisms that contribute to the maintenance of basal bodies remain to be discovered. Bld10/Cep135 is a basal body outer cartwheel domain protein that has established roles in the assembly of nascent basal bodies. We find that Bld10 protein first incorporates stably at basal bodies early during new assembly. Bld10 protein continues to accumulate at basal bodies after assembly, and we hypothesize that the full complement of Bld10 is required to stabilize basal bodies. We identify a novel mechanism for Bld10/Cep135 in basal body maintenance so that basal bodies can withstand the forces produced by motile cilia. Bld10 stabilizes basal bodies by promoting the stability of the A- and C-tubules of the basal body triplet microtubules and by properly positioning the triplet microtubule blades. The forces generated by ciliary beating promote basal body disassembly in bld10Δ cells. Thus Bld10/Cep135 acts to maintain the structural integrity of basal bodies against the forces of ciliary beating in addition to its separable role in basal body assembly.
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