ArticleJournal of virology2013
Structure of the St. Louis encephalitis virus postfusion envelope trimer.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.Viral immunology · 2017Pooled it
- Rapid virus-free production of recombinant yellow fever virus envelope protein and its in-depth biophysical analysis.Scientific reports · 2025Article
- Impact of structural dynamics on biological functions of flaviviruses.The FEBS journal · 2023Review
- Isolation of a novel insect-specific flavivirus with immunomodulatory effects in vertebrate systems.Virology · 2021Article
- Identification of Zika Virus Inhibitors Using Homology Modeling and Similarity-Based Screening to Target Glycoprotein E.Biochemistry · 2020Article
- Extensive flavivirus E trimer breathing accompanies stem zippering of the post-fusion hairpin.EMBO reports · 2020Article
- CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection.Frontiers in immunology · 2020Article
- Molecular Basis of a Protective/Neutralizing Monoclonal Antibody Targeting Envelope Proteins of both Tick-Borne Encephalitis Virus and Louping Ill Virus.Journal of virology · 2019Article
- Article
- Early Events in Japanese Encephalitis Virus Infection: Viral Entry.Pathogens (Basel, Switzerland) · 2018Review
- Insertion of Dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations.Biochimica et biophysica acta. Biomembranes · 2018Article
- New insights into flavivirus biology: the influence of pH over interactions between prM and E proteins.Journal of computer-aided molecular design · 2017Article
- Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability.Nature communications · 2017Article
- Article
- Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation.PLoS pathogens · 2016Article
- A humanized monoclonal antibody neutralizes yellow fever virus strain 17D-204 in vitro but does not protect a mouse model from disease.Antiviral research · 2016Article
- Relating structure to evolution in class II viral membrane fusion proteins.Current opinion in virology · 2014Review
- Review
- Atomic-level functional model of dengue virus Envelope protein infectivity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Structure of a dengue virus envelope protein late-stage fusion intermediate.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
St. Louis encephalitis virus (SLEV) is a mosquito-borne flavivirus responsible for several human encephalitis outbreaks over the last 80 years. Mature flavivirus virions are coated with dimeric envelope (E) proteins that mediate attachment and fusion with host cells. E is a class II fusion protein, the hallmark of which is a distinct dimer-to-trimer rearrangement that occurs upon endosomal acidification and insertion of hydrophobic fusion peptides into the endosomal membrane. Herein, we report the crystal structure of SLEV E in the posfusion trimer conformation. The structure revealed specific features that differentiate SLEV E from trimers of related flavi- and alphaviruses. SLEV E fusion loops have distinct intermediate spacing such that they are positioned further apart than previously observed in flaviviruses but closer together than Semliki Forest virus, an alphavirus. Domains II and III (DII and DIII) of SLEV E also adopt different angles relative to DI, which suggests that the DI-DII joint may accommodate spheroidal motions. However, trimer interfaces are well conserved among flaviviruses, so it is likely the differences observed represent structural features specific to SLEV function. Analysis of surface potentials revealed a basic platform underneath flavivirus fusion loops that may interact with the anionic lipid head groups found in membranes. Taken together, these results highlight variations in E structure and assembly that may direct virus-specific interactions with host determinants to influence pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.