ArticleJournal of virology2013
Inefficient vaginal transmission of tenofovir-resistant HIV-1.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Article
- ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions.The Journal of clinical investigation · 2016Article
- Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection.Antimicrobial agents and chemotherapy · 2015Article
- Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques.Retrovirology · 2015Article
- BLT humanized mice as a small animal model of HIV infection.Current opinion in virology · 2015Review
- Generation of improved humanized mouse models for human infectious diseases.Journal of immunological methods · 2014Review
- Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency.PloS one · 2014Article
- Article
- HIV-specific CD8⁺ T-cell immunity in humanized bone marrow-liver-thymus mice.The Journal of infectious diseases · 2013Review
- Overcoming current limitations in humanized mouse research.The Journal of infectious diseases · 2013Review
- In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis.Retrovirology · 2013Article
- A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.Antimicrobial agents and chemotherapy · 2013Article
- Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Transmission of drug-resistant HIV has been postulated to be a threat to current first-line antiretroviral therapy (ART) regimens and the efficacy of several antiretroviral-based preexposure prophylaxis (PrEP) strategies being tested. Here we evaluated the effect of the common tenofovir (TFV) resistance mutation K65R on vaginal HIV transmission. Our results demonstrate that despite no overt loss of overall replication competence in vivo, this mutation results in significantly reduced mucosal transmission. When transmitted, the mutant virus eventually reverted to the wild type in 2 of 3 animals examined.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.