ArticleJournal of virology2013
Mapping viral functional domains for genetic diversity in plants.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Impact of Cultivated Hosts on the Recombination ofJournal of virology · 2019Article
- Chikungunya Virus Fidelity Variants Exhibit Differential Attenuation and Population Diversity in Cell Culture and Adult Mice.Journal of virology · 2019Article
- Gauging genetic diversity of generalists: A test of genetic and ecological generalism with RNA virus experimental evolution.Virus evolution · 2019Article
- Analysis of quasispecies variation in single and mixed viral infection.Virus evolution · 2017Article
- A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses.eLife · 2017Article
- Mutation and recombination frequencies reveal a biological contrast within strains of Cucumber mosaic virus.Journal of virology · 2015Article
- Variation in RNA virus mutation rates across host cells.PLoS pathogens · 2014Article
- Fixation of emerging interviral recombinants in cucumber mosaic virus populations.Journal of virology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cucumber mosaic virus (CMV) comprises numerous isolates with various levels of in-host diversity. Subgroup-distinctive features of the Fny and LS strains provided us with a platform to genetically map the viral control elements for genetic variation in planta. We found that both RNAs 1 and 2 controlled levels of genetic diversity, and further fine mapping revealed that the control elements of mutation frequency reside within the first 596 amino acids (aa) of RNA 1. The 2a/2b overlapping region of the 2a protein also contributed to control of viral genetic variation. Furthermore, the 3' nontranslated region (NTR) of RNA 3 constituted a hot spot of polymorphism, where the majority of fixed mutations found in the population were clustered. The 2b gene of CMV, a viral suppressor of gene silencing, controls the abundance of the fixed mutants in the viral population via a host-dependent mechanism.
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Registered trials
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