ArticleJournal of clinical microbiology2013
Identification by full-genome analysis of a bovine rotavirus transmitted directly to and causing diarrhea in a human child.
Article in Journal of clinical microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Evaluating the Structural Stability of Recombinant Rotavirus Capsid Protein VP6 in Altered Physicochemical States Using Fluorescence and CD Spectroscopy.The protein journal · 2026Article
- Molecular Characterization of Rotavirus From Under-Five Children Presenting With Diarrhea at a Tertiary Hospital in Northeast Nigeria.International journal of pediatrics · 2026Article
- Interspecies Transmission of Animal Rotaviruses to Humans: Reassortment-Driven Adaptation.Pathogens (Basel, Switzerland) · 2025Review
- Prevalence and genetic characterization of diarrhea viruses among cattle in Guangdong, China.BMC veterinary research · 2025Article
- Comparative Insights into Acute Gastroenteritis in Cattle Caused by Bovine Rotavirus A and Bovine Coronavirus.Veterinary sciences · 2024Review
- Prevalence, genotype diversity, and zoonotic potential of bovine rotavirus A in Amhara National Regional State, Ethiopia: A multicenter cross-sectional study.Virus research · 2024Article
- Evolution of DS-1-like G8P[8] rotavirus A strains from Vietnamese children with acute gastroenteritis (2014-21): Adaptation and loss of animal rotavirus-derivedVirus evolution · 2024Article
- Detection of the dominant pathogens in diarrheal calves of Ningxia, China in 2021-2022.Frontiers in veterinary science · 2023Article
- Complete Genome Sequencing Reveals Unusual Equine Rotavirus A of Bat Origin from India.Journal of virology · 2022Article
- G and P genotype profiles of rotavirus a field strains circulating in a vaccinated bovine farm as parameters for assessing biosecurity level.The Journal of veterinary medical science · 2022Article
- Cross-sectional study and genotyping of rotavirus-A infections in ruminants in Kuwait.BMC veterinary research · 2021Article
- A G3P[13] porcine group A rotavirus emerging in China is a reassortant and a natural recombinant in the VP4 gene.Transboundary and emerging diseases · 2018Article
- Rotavirus A in wild and domestic animals from areas with environmental degradation in the Brazilian Amazon.PloS one · 2018Article
- Review
- Dynamics of Virus Distribution in a Defined Swine Production Network Using Enteric Viruses as Molecular Markers.Applied and environmental microbiology · 2017Article
- Article
- Molecular epidemiology of rotavirus in cats in the United Kingdom.Journal of clinical microbiology · 2015Article
- Genetic diversity of porcine group A rotavirus strains in the UK.Veterinary microbiology · 2014Article
- Critical role of cellular cholesterol in bovine rotavirus infection.Virology journal · 2014Article
- G8 rotaviruses with conserved genotype constellations detected in Malawi over 10 years (1997-2007) display frequent gene reassortment among strains co-circulating in humans.The Journal of general virology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome of rotaviruses consists of 11 segments of double-stranded RNA, and each genome segment has multiple genotypes. Thus, the genotype constellation of an isolate is often indicative of its host species. Albeit rarely, interspecies transmission occurs either by virions with nonreassorted or reassorted genomic segments. A rotavirus with the G6P[1] genotype, Ro8059, was isolated from the stool of a 1-year-old child during routine characterization of diarrheal specimens from a sentinel clinic in Israel in 1995. Since genotype G6P[1] is generally associated with bovine rotaviruses, and the child developed diarrhea within days of his first contact with calves at an urban farm, the aim of this study was to characterize the whole genomic constellation of Ro8059 and four G6P[1] bovine strains, BRV101, BRV105, BRV106, and CR231/39, by RNA-RNA hybridization and full genome sequencing to determine whether some or all of the segments were of bovine origin. The genome constellations of all four bovine G6P[1] strains were G6-P[1]-I2-R2-C2-M2-A3-N2-T6-E2-H3 for VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5, respectively. Ro8059 shared the same genotype constellation with these bovine strains, with high nucleotide sequence identities (95.84 to 100%) for each of the 11 segments indicating that Ro8059 represented a direct interspecies whole-genome transmission of a nonreassorted rotavirus from a calf to a human infant. We conclude that this was the earliest example with a complete epidemiological link in which an entirely bovine rotavirus directly infected a human child and caused a symptomatic diarrheal illness. Thus, not all bovine rotaviruses are always naturally attenuated to the human host.
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