Evidence map›Paper›PMID 23115195›Full record

Trial reportThe Journal of neuroscience : the official journal of the Society for Neuroscience2012

Cognitive-affective neural plasticity following active-controlled mindfulness intervention.

Micah Allen, Martin Dietz, Karina S Blair, Martijn van Beek, Geraint Rees, Peter Vestergaard-Poulsen, Antoine Lutz, Andreas Roepstorff

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  10. Neural Correlates Involved in Behavioral Metrics of Emotion Regulation and Suicidal Thoughts and Behaviors.Archives of suicide research : official journal of the International Academy for Suicide Research
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  15. Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023
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94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Micah AllenMINDLab, Center of Functionally Integrative Neuroscience, Aarhus University, 8000 Aarhus, Denmark. micah@cfin.dk
Martin Dietz
Karina S Blair
Martijn van Beek
Geraint Rees
Peter Vestergaard-Poulsen
Antoine Lutz
Andreas Roepstorff

Funding

Wisconsin Center for the Neuroscience and Psychophysiology of MeditationP01AT004952 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 2008 to 2018
$14.7M
NCCIH NIH HHS P01 AT004952NCCIH NIH HHS P01-AT004952Wellcome Trust 082334Wellcome Trust 091593
6 · The paper itself

Abstract

Mindfulness meditation is a set of attention-based, regulatory, and self-inquiry training regimes. Although the impact of mindfulness training (MT) on self-regulation is well established, the neural mechanisms supporting such plasticity are poorly understood. MT is thought to act through interoceptive salience and attentional control mechanisms, but until now conflicting evidence from behavioral and neural measures renders difficult distinguishing their respective roles. To resolve this question we conducted a fully randomized 6 week longitudinal trial of MT, explicitly controlling for cognitive and treatment effects with an active-control group. We measured behavioral metacognition and whole-brain blood oxygenation level-dependent (BOLD) signals using functional MRI during an affective Stroop task before and after intervention in healthy human subjects. Although both groups improved significantly on a response-inhibition task, only the MT group showed reduced affective Stroop conflict. Moreover, the MT group displayed greater dorsolateral prefrontal cortex responses during executive processing, consistent with increased recruitment of top-down mechanisms to resolve conflict. In contrast, we did not observe overall group-by-time interactions on negative affect-related reaction times or BOLD responses. However, only participants with the greatest amount of MT practice showed improvements in response inhibition and increased recruitment of dorsal anterior cingulate cortex, medial prefrontal cortex, and right anterior insula during negative valence processing. Our findings highlight the importance of active control in MT research, indicate unique neural mechanisms for progressive stages of mindfulness training, and suggest that optimal application of MT may differ depending on context, contrary to a one-size-fits-all approach.

Indexed as

AdolescentAdultAffectAttentionAwarenessCognitionEmotionsFemaleHumansImage Processing, Computer-AssistedLongitudinal StudiesMagnetic Resonance ImagingMaleMeditationMiddle AgedNeuronal PlasticityOxygen

Identifiers

PMID23115195
PMCPMC4569704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.