ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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42 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
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- Abnormal modulation of reward versus punishment learning by a dopamine D2-receptor antagonist in pathological gamblers.Psychopharmacology · 2015Trial
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- Thoughts from the forest floor: a review of cognition in the slime mould Physarum polycephalum.Animal cognition · 2023Review
- Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway.Progress in neurobiology · 2022Article
- Learning as filtering: Implications for spike-based plasticity.PLoS computational biology · 2022Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- Dissociable dopaminergic and pavlovian influences in goal-trackers and sign-trackers on a model of compulsive checking in OCD.Psychopharmacology · 2020Article
- Challenges and Opportunities in Animal Models of Gambling-like Behavior.Current opinion in behavioral sciences · 2020Article
- Irrational Responses to Risk Preference Questionnaires by Patients with Diabetes with or without Retinopathy and Comparison with Those without Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Can Slot-Machine Reward Schedules Induce Gambling Addiction in Rats?Journal of gambling studies · 2019Article
- Understanding Addiction Using Animal Models.Frontiers in behavioral neuroscience · 2019Article
- Review: brain neurobiology of gambling disorder based on rodent models.Neuropsychiatric disease and treatment · 2019Review
- Amphetamine primes enhanced motivation toward uncertain choices in rats with genetic alcohol preference.Psychopharmacology · 2018Article
- Modeling risky decision-making in nonhuman animals: shared core features.Current opinion in behavioral sciences · 2017Article
- Gambling disorder: an integrative review of animal and human studies.Annals of the New York Academy of Sciences · 2017Review
- Fractionating impulsivity: neuropsychiatric implications.Nature reviews. Neuroscience · 2017Review
- Chronic administration of the dopamine DPsychopharmacology · 2017Article
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5 authors at 1 institution in 1 country.
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Abstract
Individual differences in dopamine (DA) signaling, including low striatal D(2/3) receptors, may increase vulnerability to substance abuse, although whether this phenotype confers susceptibility to nonchemical addictions is unclear. The degree to which people use "irrational" cognitive heuristics when choosing under uncertainty can determine whether they find gambling addictive. Given that dopaminergic projections to the striatum signal reward expectancy and modulate decision-making, individual differences in DA signaling could influence the extent of such biases. To test this hypothesis, we used a novel task to model biased, risk-averse decision-making in rats. Animals chose between a "safe" lever, which guaranteed delivery of the wager, or an "uncertain" lever, which delivered either double the wager or nothing with 50:50 odds. The bet size varied from one to three sugar pellets. Although the amount at stake did not alter the options' utility, a subgroup of "wager-sensitive" rats increased their preference for the safe lever as the bet size increased, akin to risk aversion. In contrast, wager-insensitive rats slightly preferred the uncertain option consistently. Amphetamine increased choice of the uncertain option in wager-sensitive, but not in wager-insensitive rats, whereas a D(2/3) receptor antagonist decreased uncertain lever choice in wager-insensitive rats alone. Micro-PET and autoradiography using [(11)C]raclopride confirmed a strong correlation between high wager sensitivity and low striatal D(2/3) receptor density. These data suggest that the propensity for biased decision-making under uncertainty is influenced by striatal D(2/3) receptor expression, and provide novel support for the hypothesis that susceptibility to chemical and behavioral addictions may share a common neurobiological basis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.