ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Axonal conduction block as a novel mechanism of prepulse inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster.Translational psychiatry · 2026Article
- The legacies of A. O. Dennis Willows and Peter A. Getting: neuroscience research usingJournal of neurophysiology · 2025Review
- Article
- Prepulse inhibition inBiology open · 2018Article
- An Argument for Amphetamine-Induced Hallucinations in an Invertebrate.Frontiers in physiology · 2018Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In prepulse inhibition (PPI), the startle response to a strong, unexpected stimulus is diminished if shortly preceded by the onset of a different stimulus. Because deficits in this inhibitory gating process are a hallmark feature of schizophrenia and certain other psychiatric disorders, the mechanisms underlying PPI are of significant interest. We previously used the invertebrate model system Tritonia diomedea to identify the first cellular mechanism for PPI--presynaptic inhibition of transmitter release from the afferent neurons (S-cells) mediating the startle response. Here, we report the involvement of a second, more powerful PPI mechanism in Tritonia: prepulse-elicited conduction block of action potentials traveling in the startle pathway caused by identified inhibitory interneurons activated by the prepulse. This example of axo-axonic conduction block--neurons in one pathway inhibiting the propagation of action potentials in another--represents a novel and potent mechanism of sensory gating in prepulse inhibition.
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