ArticleHuman pathology2013
Expression of hepatocyte epidermal growth factor receptor, FAS and glypican 3 in EpCAM-positive regenerative clusters of hepatocytes, cholangiocytes, and progenitor cells in human liver failure.
Article in Human pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- The Values and Perspectives of Organoids in the Field of Metabolic Syndrome.International journal of molecular sciences · 2023Review
- Bipotent transitional liver progenitor cells contribute to liver regeneration.Nature genetics · 2023Article
- A new pathological classification of intrahepatic cholangiocarcinoma according to protein expression of SSTR2 and Bcl2.World journal of surgical oncology · 2021Article
- Liver regeneration: biological and pathological mechanisms and implications.Nature reviews. Gastroenterology & hepatology · 2021Review
- Depletion of T cellsFrontiers in immunology · 2021Article
- Shedding light on the EpCAM: An overview.Journal of cellular physiology · 2019Review
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- Cells responsible for liver mass regeneration in rats with 2-acetylaminofluorene/partial hepatectomy injury.Journal of biomedical science · 2018Article
- Cellular Mechanisms of Liver Regeneration and Cell-Based Therapies of Liver Diseases.BioMed research international · 2017Review
- The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?Hepatology (Baltimore, Md.) · 2016Review
- Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin.Stem cells international · 2016Review
- Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver.Medical molecular morphology · 2015Article
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- Article
- The plastic liver: differentiated cells, stem cells, every cell?The Journal of clinical investigation · 2014Article
- Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells.Hepatology (Baltimore, Md.) · 2014Article
- The liver is a peculiar organ when it comes to stem cells.The American journal of pathology · 2014Article
- Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Liver regeneration under normal circumstances proceeds through proliferation of all cellular elements of the liver. Studies with rodent models have shown that when proliferation of hepatocytes is inhibited, progenitor cells arising from the biliary compartment transdifferentiate into "oval/progenitor" cells, which proceed to differentiate into hepatocytes. Recent studies have shown that the same pathways may operate in human liver failure. The growth factor receptors (HGF [hepatocyte growth factor] receptor) and epidermal growth factor receptor are key mitogenic receptors for both hepatocytes and progenitor cells. Our current study used the biliary and progenitor marker EpCAM (epithelial cell adhesion molecule) to detect "regenerative clusters" of mixed cholangiocyte-hepatocyte differentiation. We determined that expression of metabolic equivalent and epidermal growth factor receptor occurs in biliary cells, progenitor cells, and hepatocytes, whereas activation of metabolic equivalent and epidermal growth factor receptor is limited to regenerative cluster hepatocytes. These histologic events are associated with expression of apoptosis-inducing FAS and mitoinhibitory protein glypican 3. Cell proliferation was overall suppressed in regenerative clusters. Transdifferentiation of biliary and progenitor cells appears to be regulated by a complex interaction of signals promoting and arresting growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.