ArticleMolecular biology reports2013
SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 82 citations in OpenAlex.
- Genes Selectively Expressed in Rat Organs.Current genomics · 2024Article
- Candidate genes for mastitis resistance in dairy cattle: a data integration approach.Journal of animal science and biotechnology · 2023Article
- Genetic polymorphisms in immune- and inflammation-associated genes and their association with bovine mastitis resistance/susceptibility.Frontiers in immunology · 2023Review
- Evaluation of candidate genotype of immune gene MBL1 associated with udder health and performance traits in dairy cattle and buffalo of India.Tropical animal health and production · 2021Article
- Article
- Identification of polymorphisms in the bovine collagenous lectins and their association with infectious diseases in cattle.Immunogenetics · 2018Article
- The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women.Disease markers · 2015Article
- The association of c.1471G>A genetic polymorphism in XRCC1 gene with lung cancer susceptibility in Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Genetic polymorphisms of XRCC1 gene and susceptibility to hepatocellular carcinoma in Chinese population.Medical oncology (Northwood, London, England) · 2014Article
- Association analysis between the c.1804C>A genetic polymorphism of XRCC1 gene and risk of hepatocellular carcinoma in Chinese population.Medical oncology (Northwood, London, England) · 2014Article
- Association between CTLA-4 genetic polymorphisms and susceptibility to osteosarcoma in Chinese Han population.Endocrine · 2014Article
- Haplotype analysis of TLR4 gene and its effects on milk somatic cell score in Chinese commercial cattle.Molecular biology reports · 2014Article
- Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Association between single-nucleotide polymorphisms of OGG1 gene and pancreatic cancer risk in Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Association analysis between g.18873C>T and g.27522G>A genetic polymorphisms of OPG and bone mineral density in Chinese postmenopausal women.BioMed research international · 2014Article
- Investigation on XRCC1 genetic polymorphism and its relationship with breast cancer risk factors in Chinese women.Medical oncology (Northwood, London, England) · 2013Article
- Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population.Genetics and molecular biology · 2013Article
- Association analyses of osteoprotegerin gene polymorphisms with bone mineral density in Chinese postmenopausal women.Medical oncology (Northwood, London, England) · 2013Article
- Association of MDR1 gene polymorphisms with the risk of hepatocellular carcinoma in the Chinese Han population.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Association study of single nucleotide polymorphisms in XRCC1 gene with the risk of gastric cancer in Chinese population.International journal of biological sciences · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate the single nucleotide polymorphisms (SNPs) within bovine binding lectin-liver (A) gene (MBL1) and to explore its correlation analysis with milk somatic cell score (SCS) which reflects mastitis resistance in cattle. Through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), created restriction site-PCR (CRS-PCR) and DNA sequencing methods, three allelic variant corresponding to the G→A mutation at c.1252G>A in intron1, G→A mutation at c.2534G>A and T→C mutation at c.2569T>C in exon2 of bovine MBL1 gene, could be detected, respectively. The c.2534G>A was a nonsynonymous mutation, resulting in Valine (Val) to Isoleucine (Ile) amino acid replacement (p.Val24Ile). The correlation analysis between the MBL1 SNPs gene and milk SCS were analyzed and a significant correlation with milk SCS was detected in c.2534G>A. The value of milk SCS for individuals with genotype GG was significantly lower than those of genotype GA and AA. Results showed that genotype GG with the lowest milk SCS was favorable for mastitis resistance, whereas genotype AA with the highest milk SCS was easily for mastitis susceptibility. Although more investigations are needed to better clarify the role of these SNPs on mastitis resistance, MBL1 polymorphism appears to be a promising indirect marker to improve dairy mastitis resistance traits in cattle.
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