ArticleVirology journal2012
Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa.
Article in Virology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- A systematic review of the epidemiology of hepatitis E virus in Africa.BMC infectious diseases · 2014Pooled it
- Hepatitis E Virus Infection in Pregnant Women.Microorganisms · 2026Review
- Hepatitis E virus seroprevalence in South Africa: a multi-site study among HIV-negative and HIV-positive adults and age-stratified children (2-17 Years).BMC infectious diseases · 2026Article
- Article
- Hepatitis E Virus (HEV) Infection Among Immunocompromised Individuals: A Brief Narrative Review.Infection and drug resistance · 2024Review
- Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal.Viruses · 2022Article
- Maternal and fetal outcomes of pregnancies complicated by acute hepatitis E and the impact of HIV status: A cross-sectional study in Namibia.Liver international : official journal of the International Association for the Study of the Liver · 2022Article
- Hepatitis E in Sub Saharan Africa - A significant emerging disease.One health (Amsterdam, Netherlands) · 2021Review
- Hepatitis E Infection in HIV-Infected Patients.Frontiers in microbiology · 2019Article
- Seroprevalence of Hepatitis E Virus Infection Among People Living With HIV in the Central African Republic.Open forum infectious diseases · 2018Article
- Sero-prevalence and risk factors for hepatitis E virus infection among pregnant women in the Cape Coast Metropolis, Ghana.PloS one · 2018Article
- Non-malarial infectious diseases of antenatal care in pregnant women in Franceville, Gabon.BMC pregnancy and childbirth · 2017Article
- Hepatitis E virus seroprevalence in HIV positive individuals in Shiraz, Southern Iran.Iranian journal of microbiology · 2015Article
- Seroepidemiology of hepatitis E virus infection in an urban population in Zambia: strong association with HIV and environmental enteropathy.The Journal of infectious diseases · 2014Article
- Fetal and neonatal health consequences of vertically transmitted hepatitis E virus infection.The American journal of tropical medicine and hygiene · 2014Review
- Host immune status and response to hepatitis E virus infection.Clinical microbiology reviews · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis E virus (HEV), an enterically transmitted pathogen, is highly endemic in several African countries. Pregnant women are at particularly high risk for acute or severe hepatitis E. In Gabon, a central African country, the prevalence of antibodies to HEV among pregnant women is 14.1%. Recent studies have demonstrated unusual patterns of hepatitis E (chronic hepatitis, cirrhosis) among immunodeficient patients.
findingsWe investigated the prevalence of antibodies to HEV among pregnant women infected with HIV-1 or HTLV-1 in Gabon. Of 243 samples collected, 183 were positive for HIV-1 and 60 for HTLV-1; 16 women (6.6%) had IgG antibodies to HEV. The seroprevalence was higher among HIV-1-infected women (7.1%) than HTLV-1-infected women (5.0%). Moreover, the HIV-1 viral load was significantly increased (p ≤ 0.02) among women with past-HEV exposure (1.3E+05 vs 5.7E+04 copies per ml), whereas no difference was found in HTLV-1 proviral load (9.0E+01 vs 1.1E+03 copies per ml).
conclusionsThese data provide evidence that HIV-1-infected women are at risk for acute or severe infection if they are exposed to HEV during pregnancy, with an increased viral load.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.