ArticleComparative medicine2012
Development of standardized insulin treatment protocols for spontaneous rodent models of type 1 diabetes.
Article in Comparative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Evaluation of in vitro and in vivo antidiabetic potential of hydromethanol extract and solvent fraction of the leaves ofMetabolism open · 2026Article
- Is the NOD mouse a good model for type 1 diabetes?Diabetologia · 2026Review
- Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways.Inflammopharmacology · 2024Article
- The protective effect of the intestinal microbiota in type-1 diabetes in NOD mice is limited to a time window in early life.Frontiers in endocrinology · 2024Article
- Rational Design and Efficacy of Glucose-Responsive Insulin Therapeutics and Insulin Delivery Systems by Computation Using Connected Human and Rodent Models.Advanced healthcare materials · 2023Article
- Polyacrylamide-based hydrogel coatings improve biocompatibility of implanted pump devices.Journal of biomedical materials research. Part A · 2023Article
- Antidiabetic Activities of 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Anti-Hyperglycemic and Hypoglycemic Activities of 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Immunoregulatory Sertoli Cell Allografts Engineered to Express Human Insulin Survive Humoral-Mediated Rejection.International journal of molecular sciences · 2022Article
- Irisin/FNDC5 influences myogenic markers on skeletal muscle following high and moderate-intensity exercise training in STZ-diabetic rats.3 Biotech · 2022Article
- Environmental enrichment preserves hippocampal neurons in diabetes and stressed rats.Histology and histopathology · 2022Article
- Metformin prevents airway hyperreactivity in rats with dietary obesity.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Moderate-Intensity Exercise Training in Association with Insulin Promotes Heat Shock Proteins 70 and 90 Expressions in Testicular Tissue of Experimental Type 1 Diabetes.Cell journal · 2021Article
- Comparative effects of high-intensity interval training and moderate-intensity continuous training on soleus muscle fibronectin type III domain-containing protein 5, myonectin and glucose transporter type 4 gene expressions: a study on the diabetic rat model.Molecular biology reports · 2021Article
- Skeletal Response to Insulin in the Naturally Occurring Type 1 Diabetes Mellitus Mouse Model.JBMR plus · 2021Article
- Insulin acutely increases agonist-induced airway smooth muscle contraction in humans and rats.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice.Frontiers in endocrinology · 2021Article
- Berberine improves insulin-induced diabetic retinopathy through exclusively suppressing Akt/mTOR-mediated HIF-1α/VEGF activation in retina endothelial cells.International journal of biological sciences · 2021Article
- Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin.Diabetes · 2020Article
- Efficacy of phage cocktail AB-SA01 therapy in diabetic mouse wound infections caused by multidrug-resistant Staphylococcus aureus.BMC microbiology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Standardized protocols for maintaining near-normal glycemic levels in diabetic rodent models for testing therapeutic agents to treat disease are unavailable. We developed protocols for 2 common models of spontaneous type 1 diabetes, the BioBreeding diabetes-prone (BBDP) rat and nonobese diabetic (NOD) mouse. Insulin formulation, dose level, timing of dose administration, and delivery method were examined and adjusted so that glycemic levels remained within a normal range and fluctuation throughout feeding and resting cycles was minimized. Protamine zinc formulations provided the longest activity, regardless of the source of insulin. Glycemic control with few fluctuations was achieved in diabetic BBDP rats through twice-daily administration of protamine zinc insulin, and results were similar regardless of whether BBDP rats were acutely or chronically diabetic at initiation of treatment. In contrast, glycemic control could not be attained in NOD mice through administration of insulin twice daily. However, glycemic control was achieved in mice through daily administration of 0.25 U insulin through osmotic pumps. Whereas twice-daily injections of protamine zinc insulin provided glycemic control with only minor fluctuations in BBDP rats, mice required continuous delivery of insulin to prevent wide glycemic excursions. Use of these standard protocols likely will aid in the testing of agents to prevent or reverse diabetes.
Indexed as
Identifiers
23114041PMC3472602What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.