ArticleBiology direct2012
Early evolution of efficient enzymes and genome organization.
Article in Biology direct, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Targeting energy, nucleotide, and DNA synthesis in cancer.Frontiers in oncology · 2025Article
- Emergence of linkage between cooperative RNA replicators encoding replication and metabolic enzymes through experimental evolution.PLoS genetics · 2023Article
- Genome Evolution from Random Ligation of RNAs of Autocatalytic Sets.International journal of molecular sciences · 2021Article
- Evolution of linkage and genome expansion in protocells: The origin of chromosomes.PLoS genetics · 2020Article
- From self-replication to replicator systems en route to de novo life.Nature reviews. Chemistry · 2020Review
- The evolutionary dynamics of metabolic protocells.PLoS computational biology · 2018Article
- The minimotif synthesis hypothesis for the origin of life.Journal of translational science · 2016Article
- Toward major evolutionary transitions theory 2.0.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- In silico ribozyme evolution in a metabolically coupled RNA population.Biology direct · 2015Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundCellular life with complex metabolism probably evolved during the reign of RNA, when it served as both information carrier and enzyme. Jensen proposed that enzymes of primordial cells possessed broad specificities: they were generalist. When and under what conditions could primordial metabolism run by generalist enzymes evolve to contemporary-type metabolism run by specific enzymes?
resultsHere we show by numerical simulation of an enzyme-catalyzed reaction chain that specialist enzymes spread after the invention of the chromosome because protocells harbouring unlinked genes maintain largely non-specific enzymes to reduce their assortment load. When genes are linked on chromosomes, high enzyme specificity evolves because it increases biomass production, also by reducing taxation by side reactions.
conclusionThe constitution of the genetic system has a profound influence on the limits of metabolic efficiency. The major evolutionary transition to chromosomes is thus proven to be a prerequisite for a complex metabolism. Furthermore, the appearance of specific enzymes opens the door for the evolution of their regulation. REVIEWERS: This article was reviewed by Sándor Pongor, Gáspár Jékely, and Rob Knight.
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