ArticleBMC biology2012
Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans.
Article in BMC biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Starvation transforms signal encoding ineLife · 2026Article
- Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.PLoS neglected tropical diseases · 2024Article
- Thermosensory behaviors of the free-living life stages ofbioRxiv : the preprint server for biology · 2024Article
- Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity.Genetics · 2023Article
- The Thermal Stress Coping Network of the NematodeInternational journal of molecular sciences · 2022Review
- Megapixel camera arrays enable high-resolution animal tracking in multiwell plates.Communications biology · 2022Article
- Review
- CaeLife · 2021Article
- Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform.Nature protocols · 2020Article
- Impaired EAT-4 Vesicular Glutamate Transporter Leads to Defective Nocifensive Response of Caenorhabditis elegans to Noxious Heat.Neurochemical research · 2020Article
- A system for the high-throughput analysis of acute thermal avoidance and adaptation inJournal of biological methods · 2020Article
- Article
- Digging deeper: methodologies for high-content phenotyping in Caenorhabditis elegans.Lab animal · 2019Review
- HowGenetics · 2019Review
- Temperature-dependent behaviors of parasitic helminths.Neuroscience letters · 2018Review
- Measuring behavior across scales.BMC biology · 2018Review
- Stereotypical Escape Behavior in Caenorhabditis elegans Allows Quantification of Effective Heat Stimulus Level.PLoS computational biology · 2016Article
- Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans.Scientific reports · 2016Article
- Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans.Genetics · 2015Article
- Experience Modulates the Reproductive Response to Heat Stress in C. elegans via Multiple Physiological Processes.PloS one · 2015Article
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4 authors.
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Abstract
backgroundResponding to noxious stimuli by invoking an appropriate escape response is critical for survival of an organism. The sensations of small and large changes in temperature in most organisms have been studied separately in the context of thermotaxis and nociception, respectively. Here we use the nematode C. elegans to address the neurogenetic basis of responses to thermal stimuli over a broad range of intensities.
resultsC. elegans responds to aversive temperature by eliciting a stereotypical behavioral sequence. Upon sensation of the noxious stimulus, it moves backwards, turns and resumes forward movement in a new direction. In order to study the response of C. elegans to a broad range of noxious thermal stimuli, we developed a novel assay that allows simultaneous characterization of multiple aspects of escape behavior elicited by thermal pulses of increasing amplitudes. We exposed the laboratory strain N2, as well as 47 strains with defects in various aspects of nervous system function, to thermal pulses ranging from ΔT = 0.4°C to 9.1°C and recorded the resulting behavioral profiles.
conclusionsThrough analysis of the multidimensional behavioral profiles, we found that the combinations of molecules shaping avoidance responses to a given thermal pulse are unique. At different intensities of aversive thermal stimuli, these distinct combinations of molecules converge onto qualitatively similar stereotyped behavioral sequences.
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