ArticleBMC neuroscience2012
Prepulse inhibition of auditory change-related cortical responses.
Article in BMC neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- The blink reflex and its modulation - Part 1: Physiological mechanisms.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Review
- Age and sex effects on paired-pulse suppression and prepulse inhibition of auditory evoked potentials.Frontiers in neuroscience · 2024Article
- Target Site of Prepulse Inhibition of the Trigeminal Blink Reflex in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Effects of Attention on the Syllable-Induced Prepulse Inhibition of the Startle Reflex and Cortical EEG Responses against Energetic or Informational Masking in Humans.Brain sciences · 2022Article
- Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers.European journal of pain (London, England) · 2022Article
- Effects of Magnitude of Leading Stimulus on Prepulse Inhibition of Auditory Evoked Cerebral Responses: An Exploratory Study.Life (Basel, Switzerland) · 2021Article
- Parallel modulation of intracortical excitability of somatosensory and visual cortex by the gonadal hormones estradiol and progesterone.Scientific reports · 2020Article
- Assessment of haptic memory using somatosensory change-related cortical responses.Human brain mapping · 2020Article
- A Gap Prepulse with a Principal Stimulus Yields a Combined Auditory Late Response.Journal of audiology & otology · 2020Article
- Article
- Suppression of Somatosensory Evoked Cortical Responses by Noxious Stimuli.Brain topography · 2019Article
- Properties of echoic memory revealed by auditory-evoked magnetic fields.Scientific reports · 2019Article
- Change-Related Acceleration Effects on Auditory Steady State Response.Frontiers in systems neuroscience · 2019Article
- Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta.Neuroscience bulletin · 2018Article
- Long-latency suppression of auditory and somatosensory change-related cortical responses.PloS one · 2018Article
- GABAergic mechanisms involved in the prepulse inhibition of auditory evoked cortical responses in humans.PloS one · 2018Article
- New paradigm for auditory paired pulse suppression.PloS one · 2017Article
- Effects of Stimulus-Driven and Goal-Directed Attention on Prepulse Inhibition of Brain Oscillations.Frontiers in human neuroscience · 2016Article
- Inhibition in the Human Auditory Cortex.PloS one · 2016Article
- Prepulse inhibition of change-related P50m no correlation with P50m gating.SpringerPlus · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrepulse inhibition (PPI) of the startle response is an important tool to investigate the biology of schizophrenia. PPI is usually observed by use of a startle reflex such as blinking following an intense sound. A similar phenomenon has not been reported for cortical responses.
resultsIn 12 healthy subjects, change-related cortical activity in response to an abrupt increase of sound pressure by 5 dB above the background of 65 dB SPL (test stimulus) was measured using magnetoencephalography. The test stimulus evoked a clear cortical response peaking at around 130 ms (Change-N1m). In Experiment 1, effects of the intensity of a prepulse (0.5 ~ 5 dB) on the test response were examined using a paired stimulation paradigm. In Experiment 2, effects of the interval between the prepulse and test stimulus were examined using interstimulus intervals (ISIs) of 50 ~ 350 ms. When the test stimulus was preceded by the prepulse, the Change-N1m was more strongly inhibited by a stronger prepulse (Experiment 1) and a shorter ISI prepulse (Experiment 2). In addition, the amplitude of the test Change-N1m correlated positively with both the amplitude of the prepulse-evoked response and the degree of inhibition, suggesting that subjects who are more sensitive to the auditory change are more strongly inhibited by the prepulse.
conclusionsSince Change-N1m is easy to measure and control, it would be a valuable tool to investigate mechanisms of sensory gating or the biology of certain mental diseases such as schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.