ArticleBiomaterials2013
Role of direct estrogen receptor signaling in wear particle-induced osteolysis.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Niobium carbide (MXene) reduces UHMWPE particle-induced osteolysis.Bioactive materials · 2022Article
- Icariin Alleviates Wear Particle-Induced Periprosthetic OsteolysisFrontiers in pharmacology · 2021Article
- Harmine Alleviates Titanium Particle-Induced Inflammatory Bone Destruction by Immunomodulatory Effect on the Macrophage Polarization and Subsequent Osteogenic Differentiation.Frontiers in immunology · 2021Article
- In vitro and in vivo Biological Responses to Graphene and Graphene Oxide: A Murine Calvarial Animal Study.International journal of nanomedicine · 2020Article
- Antiresorptive Agents are More Effective in Preventing Titanium Particle-Induced Calvarial Osteolysis in Ovariectomized Mice Than Anabolic Agents in Short-Term Administration.Artificial organs · 2018Article
- Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing.Regenerative engineering and translational medicine · 2016Article
- Icariin attenuates titanium-particle inhibition of bone formation by activating the Wnt/β-catenin signaling pathway in vivo and in vitro.Scientific reports · 2016Article
- Local delivery of mutant CCL2 protein-reduced orthopaedic implant wear particle-induced osteolysis and inflammation in vivo.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Are biologic treatments a potential approach to wear- and corrosion-related problems?Clinical orthopaedics and related research · 2014Review
- Mutant monocyte chemoattractant protein 1 protein attenuates migration of and inflammatory cytokine release by macrophages exposed to orthopedic implant wear particles.Journal of biomedical materials research. Part A · 2014Article
- Toll-like receptors-2 and 4 are overexpressed in an experimental model of particle-induced osteolysis.Journal of biomedical materials research. Part A · 2014Article
- Direct subcutaneous injection of polyethylene particles over the murine calvaria results in dramatic osteolysis.International orthopaedics · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
Estrogen withdrawal following surgical ovariectomy was recently shown to mitigate particle-induced osteolysis in the murine calvarial model. Currently, we hypothesize that estrogen receptors (ERs) were involved in this paradoxical phenomenon. To test this hypothesis, we first evaluated polyethylene (PE) particle-induced osteolysis in the murine calvarial model, using wild type (WT) C57BL6J female mice, ERα deficient (ERαKO) mice, and WT mice either treated with 17β-estradiol (E2) or with the ER pan-antagonist ICI 182,780. According to micro-CT and histomorphometry, we showed that bone resorption was consistently altered in both ERαKO and ICI 182,780 treated mice as compared to WT and E2 groups. Then, we demonstrated that ER disruption consistently decreased both PE and polymethylmethacrylate (PMMA) particle-induced production of TNF-α by murine macrophages in vitro. Similar results were obtained following ER blockade using ICI 182,780 in RAW 264.7 and WT macrophages. ER disruption and pre treatment with ICI 182,780 resulted in a consistent down-regulation of particle-induced TNF-α mRNA expression relative to WT macrophages or untreated RAW cells. These results indicate that the response to wear particles involves estrogen receptors in female mice, as part of macrophage activation. Estrogen receptors may be considered as a future therapeutic target for particle-induced osteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.