ArticleLaterality2013
Lack of an association between left-handedness and APOE polymorphism in a large sample of adults: results of the Czech HAPIEE study.
Article in Laterality, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 13 citations in OpenAlex.
- Sex differences in APOE- and PICALM-related cognitive profiles in healthy middle-aged adults.Frontiers in aging · 2025Article
- The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses.Frontiers in psychology · 2017Article
- The genetic relationship between handedness and neurodevelopmental disorders.Trends in molecular medicine · 2014Review
- Handedness genetics: considering the phenotype.Frontiers in psychology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
An association between APOE genotype and left-handedness has been previously reported. We examined whether such association exists in a population sample of 4438 unrelated Caucasian adults aged 45-69 years (2022 males and 2416 females). Left-handedness was based on self-reported left-hand dominance for writing (prevalence 4.9%) and on consistently higher left-hand grip strength in two repeated measurements (prevalence 12.2%). Individuals with higher left hand grip strength were seven times more likely to be self-reported left handers (p<.0001, χ(2) 159.7, 2 df). There were no differences in the proportion of self-reported left-handedness (p=.828, χ(2) 2.1, 5 df) or higher grip strength in left hand (p=.557, χ(2) 3.9, 5 df) between APOE genotypes. The lack of association was similar in both genders and did not differ by age group. The results suggest that left-handedness in adults is not related to APOE genotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.