ArticleIranian journal of public health2012
Effect of Curcumin on Aspergillus parasiticus Growth and Expression of Major Genes Involved in the Early and Late Stages of Aflatoxin Biosynthesis.
Article in Iranian journal of public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Protocatechuic acid inhibits aflatoxin production and modulates gene expression in Aspergillus flavus.Scientific reports · 2025Article
- Inhibitive effect of Urginea epigea methanolic extract and silver/zinc oxide nanoparticles on Aspergillus and aflatoxin production.PloS one · 2025Article
- Estragole Inhibits Growth and Aflatoxin Biosynthesis ofMicrobiology spectrum · 2023Article
- Inhibition ofToxins · 2022Article
- Curcumin-Based Photosensitization, a Green Treatment in InactivatingFoods (Basel, Switzerland) · 2022Article
- The effect of Propolis on inhibition ofJournal of environmental health science & engineering · 2020Article
- Review
- Antifungal activity of eugenol onCurrent medical mycology · 2020Article
- Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation.Drug delivery · 2019Article
- Unraveling the importance of molecules of natural origin in antifungal drug development through targeting ergosterol biosynthesis pathway.Iranian journal of microbiology · 2019Review
- New micelle myricetin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment.Drug delivery · 2019Article
- Cinnamaldehyde, a Promising Natural Preservative AgainstFrontiers in microbiology · 2019Article
- Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin.International journal of nanomedicine · 2019Article
- Article
- Investigation the Effects of Lactobacillus acidophilus and Lactobacillus casei on aflR Gene expression in Aspergillus parasiticus by Real Time-PCR.Iranian journal of public health · 2016Article
- Inhibitory Effects of Silver Nanoparticles on Growth and Aflatoxin B1 Production by Aspergillus Parasiticus.Iranian journal of medical sciences · 2015Article
- Inhibitory effect of eugenol on aflatoxin B1 production in Aspergillus parasiticus by downregulating the expression of major genes in the toxin biosynthetic pathway.World journal of microbiology & biotechnology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of curcumin as a natural safe compound with different biological activities was examined on fungal growth and aflatoxin production in Aspergillus parasiticus NRRL 2999.
methodsThe fungus was cultured in presence of serial two-fold concentrations of curcumin (125-2000 μg/ml) in yeast extract sucrose broth for 3 days at 28°C. Mycelia dry weight was determined as an index of fungal growth, while aflatoxin production was assessed by high performance liquid chromatography (HPLC). The expression of ver-1, nor-1, pksA, omtA and aflR genes in aflatoxin biosynthetic pathway was evaluated by real time PCR.
resultsCurcumin strongly inhibited aflatoxin B(1) production in the range of 26.6 to 94.9% by serial two-fold concentrations from 125 to 2000 μg/ml. Fungal growth was also inhibited by the compound in the range of 34.0 to 60.8%. Analysis of the expression of aflatoxin pathway genes by real time PCR showed that curcumin inhibited the expression of ver-1, nor-1, pksA, omtA and aflR genes at concentrations of 250 and 1000 μg/ml. In concentration of 1000 μg/ml, gene expression was reduced by 31.3%, 44.6%, 57.1% 110.9% and 286.7% accordingly. Reduction in the expression of aflatoxin biosynthesis genes was significant only for aflR. In ferric reducing ability of plasma (FRAP) assay, curcumin showed strong antioxidant activity at all concentrations tested.
conclusionCurcumin may be employed successfully as a good candidate in controlling of toxigenic fungal growth on food and feed and subsequent contamination with aflatoxins in practice.
Indexed as
Identifiers
23113196PMC3469004W2163184078What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.