ArticleIranian journal of public health2010
In vivo efficacy of gum obtained pistacia atlantica in experimental treatment of cutaneous leishmaniasis.
Article in Iranian journal of public health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Pistacia atlantica sub. Kurdica can improve insulin resistance in patients with non-alcoholic fatty liver disease: a randomized clinical trial.BMC complementary medicine and therapies · 2026Trial
- Pistacia atlantica can improve oxidative status in patients with metabolic dysfunction-associated fatty liver disease.Scientific reports · 2025Trial
- Chemical Characterization and Leishmanicidal Activity In Vitro and In Silico of Natural Products Obtained from Leaves ofMetabolites · 2023Article
- Anti Leishmanial Effect ofJournal of arthropod-borne diseases · 2022Article
- Application of active Kurdi gum and Farsi gum-based coatings in banana fruits.Journal of food science and technology · 2020Article
- Effect ofWorld journal of plastic surgery · 2018Article
- Phytochemical analysis and antioxidant and anticancer activities of mastic gum resin fromOncoTargets and therapy · 2018Article
- Medicinal plants with promising antileishmanial activity in Iran: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2017Review
- Effects ofJundishapur journal of microbiology · 2016Article
- Antimicrobial effect of Pistacia atlantica leaf extract.Bioinformation · 2016Article
- In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- In Vitro and In Vivo Antileishmanial Effects of Pistacia khinjuk against Leishmania tropica and Leishmania major.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effects of a fixed-intensity of endurance training and pistacia atlantica supplementation on ATP-binding cassette G4 expression.Chinese medicine · 2013Article
- Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): a review of their traditional uses, phytochemistry, and pharmacology.TheScientificWorldJournal · 2013Review
- Evaluation of the protective and therapeutic effects ofAvicenna journal of phytomedicineArticle
- Efficacy of a Combined Herbal Product ContainingIranian journal of parasitologyArticle
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent circumstantial evidences are suggesting that an increasing number of Iranian patients with cutaneous leishmaniasis are unresponsive to meglumine antimoniate (Glucantime®). Pistacia atlantica is native plant in Iran (central, western, and eastern regions). Gum obtained Pistacia atlantica has been reported to possess considerable in vitro antimicrobial activity. In this study, we aimed to investigate antileishmanial activity of P. atlantica.
methodsMale BALB/c mice were inoculated subcutaneously 2×10(6)L. major Promastigotes (MHROM/IR/75/ER) at the base of tail in 2007. Mice were randomly divided into 3 groups. in group 1 Glucantime® was administered to the BALB/c mice in regimen of 60 mg per kg of body weight for 28 days by intraperitoneal injections per day, in group 2 the gum of P. atlantica var. Kurdica were tested by rubbing of local lesions for 28 days, group 3 infected but non-treated. Comparisons of treated groups and untreated group were done by two-way analysis of variance (ANOVA)
resultsTopically rubbing administration of gum obtained P. atlantica var. kurdica daily for 28 days like Glucantime® decreased skin lesion size in the BALB/c mice infected with L. major compared with that in the control (P< 0.01). Treatment BALB/c mice with gum obtained P. atlantica var. kurdica and Glucantime® causes decrease number of parasitologicaly positive mice (P< 0.05).
conclusionOur results show that gum obtained P. atlantica var. kurdica can be used for controlling cutaneous leishmaniasis caused by L. major and inhibiting development of cutaneous leishmaniasis lesions.
Indexed as
Identifiers
23112988PMC3468973W2166853866What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.