ReviewNutrients2012
Consequences of essential fatty acids.
Review in Nutrients, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Trial
- Methodology for altering omega-3 EPA+DHA and omega-6 linoleic acid as controlled variables in a dietary trial.Clinical nutrition (Edinburgh, Scotland) · 2021Trial
- Review
- Fatty acid composition of ground-beef products and their plant-based meat substitutes available in Hungary.Frontiers in nutrition · 2026Article
- Impact of a soybean oil-enriched diet on metabolic parameters in a chick model of childhood obesity.Veterinary research forum : an international quarterly journal · 2026Article
- Effect of Formulated Edible Oils From Groundnut and African Walnut Oils on Some Hematological, Inflammation, and Oxidative Stress Markers in High-Fat Diet-Induced Obese Wistar Rats.Food science & nutrition · 2025Article
- Replacement of saturated fatty acids with linoleic acid in western diet attenuates atherosclerosis in a mouse model with inducible ablation of hepatic LDL receptor.Scientific reports · 2023Article
- Review
- Effects of Repeated Heating on Fatty Acid Composition of Plant-Based Cooking Oils.Foods (Basel, Switzerland) · 2022Article
- Effects of Three-Month Feeding High Fat Diets with Different Fatty Acid Composition on Myocardial Proteome in Mice.Nutrients · 2021Article
- A bacterial biosynthetic pathway for methylated furan fatty acids.The Journal of biological chemistry · 2020Article
- Article
- Single-Dose SDA-Rich Echium Oil Increases Plasma EPA, DPAn3, and DHA Concentrations.Nutrients · 2019Article
- Profiling DNA methylation patterns of zebrafish liver associated with parental high dietary arachidonic acid.PloS one · 2019Article
- Analysis of the Lipid Profile in Patients with Colorectal Cancer in Advanced StagesAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Associations between fatty acids and low-grade inflammation in children from the LISAplus birth cohort study.European journal of clinical nutrition · 2017Article
- Anti-obesity effect of a traditional Chinese dietary habit-blending lard with vegetable oil while cooking.Scientific reports · 2017Article
- Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice.Scientific reports · 2017Article
- Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa.Prostaglandins & other lipid mediators · 2017Article
- Arachidonic acid and Docosahexanoic acid enhance platelet formation from human apheresis-derived CD34Cell cycle (Georgetown, Tex.) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Essential fatty acids (EFA) are nutrients that form an amazingly large array of bioactive mediators that act on a large family of selective receptors. Nearly every cell and tissue in the human body expresses at least one of these receptors, allowing EFA-based signaling to influence nearly every aspect of human physiology. In this way, the health consequences of specific gene-environment interactions with these nutrients are more extensive than often recognized. The metabolic transformations have similar competitive dynamics for the n-3 and n-6 homologs when converting dietary EFA from the external environment of foods into the highly unsaturated fatty acid (HUFA) esters that accumulate in the internal environment of cells and tissues. In contrast, the formation and action of bioactive mediators during tissue responses to stimuli tend to selectively create more intense consequences for n-6 than n-3 homologs. Both n-3 and n-6 nutrients have beneficial actions, but many common health disorders are undesired consequences of excessive actions of tissue n-6 HUFA which are preventable. This review considers the possibility of preventing imbalances in dietary n-3 and n-6 nutrients with informed voluntary food choices. That action may prevent the unintended consequences that come from eating imbalanced diets which support excessive chronic actions of n-6 mediators that harm human health. The consequences from preventing n-3 and n-6 nutrient imbalances on a nationwide scale may be very large, and they need careful evaluation and implementation to avoid further harmful consequences for the national economy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.