ArticlePloS one2012
Extremely rare interbreeding events can explain neanderthal DNA in living humans.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- An amphibian species pushed out of Britain by a moving hybrid zone.Molecular ecology · 2019Article
- Disease transmission and introgression can explain the long-lasting contact zone of modern humans and Neanderthals.Nature communications · 2019Article
- Article
- A parsimonious neutral model suggests Neanderthal replacement was determined by migration and random species drift.Nature communications · 2017Article
- On the antiquity of language: the reinterpretation of Neandertal linguistic capacities and its consequences.Frontiers in psychology · 2013Article
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2 authors.
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Abstract
Considering the recent experimental discovery of Green et al that present-day non-Africans have 1 to [Formula: see text] of their nuclear DNA of Neanderthal origin, we propose here a model which is able to quantify the genetic interbreeding between two subpopulations with equal fitness, living in the same geographic region. The model consists of a solvable system of deterministic ordinary differential equations containing as a stochastic ingredient a realization of the neutral Wright-Fisher process. By simulating the stochastic part of the model we are able to apply it to the interbreeding of the African ancestors of Eurasians and Middle Eastern Neanderthal subpopulations and estimate the only parameter of the model, which is the number of individuals per generation exchanged between subpopulations. Our results indicate that the amount of Neanderthal DNA in living non-Africans can be explained with maximum probability by the exchange of a single pair of individuals between the subpopulations at each 77 generations, but larger exchange frequencies are also allowed with sizeable probability. The results are compatible with a long coexistence time of 130,000 years, a total interbreeding population of order [Formula: see text] individuals, and with all living humans being descendants of Africans both for mitochondrial DNA and Y chromosome.
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