ArticleJournal of conservative dentistry : JCD2012
Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex.
Article in Journal of conservative dentistry : JCD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Approaches to regenerative endodontic therapy in necrotic human teeth with complete root formation: a systematic review.Clinical oral investigations · 2025Pooled it
- Are platelet concentrate scaffolds superior to traditional blood clot scaffolds in regeneration therapy of necrotic immature permanent teeth? A systematic review and meta-analysis.BMC oral health · 2022Pooled it
- Biocompatibility of carbazochrome sodium sulfonate on human dental pulp stem cells: AnJournal of conservative dentistry and endodontics · 2026Article
- Smart Hydrogels for Craniofacial Regeneration.Cells · 2026Review
- Evaluation of dentin bridge formation and postoperative pain reduction after direct pulp capping using photobiomodulation therapy, platelet-rich fibrin, and mineral trioxide aggregate - A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Advantages of horizontal centrifugation of platelet-rich fibrin in regenerative medicine and dentistry.Periodontology 2000 · 2025Review
- The use of platelet-rich fibrin in maintaining vascularity for intentionally replanted teeth: A randomized clinical trial.JADA foundational science · 2025Article
- Platelet-Rich Fibrin: A Self-Derived Biomaterial for Surgical Treatment of a Periapical Lesion.Cureus · 2024Article
- Role of Platelet Concentrates in Dental-Pulp Regeneration: A Systematic Review of Randomized Clinical Trials.Journal of dentistry (Shiraz, Iran) · 2024Review
- Mines of cytokine: A treasure trove in pulpal and periapical diseases.Journal of conservative dentistry and endodontics · 2024Review
- Platelet-Rich Fibrin (PRF) and its Application in Dentistry: A Literature Review.Journal of pharmacy & bioallied sciences · 2024Review
- Revascularization of a Permanent Tooth with Necrotic Pulp and Apical Periodontitis.Clinical, cosmetic and investigational dentistry · 2024Article
- Surgical Management of Radicular Cyst With the Application of a Natural Platelet Concentrate: A Case Report.Cureus · 2023Article
- Macro, Micro, and Nano-Inspired Bioactive Polymeric Biomaterials in Therapeutic, and Regenerative Orofacial Applications.Drug design, development and therapy · 2023Review
- Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends.International journal of molecular sciences · 2022Review
- Management of internal inflammatory root resorption using injectable platelet-rich fibrin revascularization technique: a clinical study with cone-beam computed tomography evaluation.Clinical oral investigations · 2022Article
- PRP and PRF-Subgroups and Divisions When Used in Dentistry.Journal of personalized medicine · 2021Review
- Management of necrotic immature permanent maxillary incisors using a modified technique of revascularisation.BMJ case reports · 2021Article
- A novel regenerative endodontic procedure in a traumatized immature tooth using amniotic membrane.Dental research journal · 2021Article
- Platelet-Rich Fibrin Used in Regenerative Endodontics and Dentistry: Current Uses, Limitations, and Future Recommendations for Application.International journal of dentistry · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regeneration of pulp-dentin complex in an infected necrotic tooth with an open apex is possible if the canal is effectively disinfected. The purpose of this case report is to add a regenerative endodontic case to the existing literature about using Platelet Rich Fibrin (PRF). A nine year old boy who accidently broke his immature maxillary central incisor tooth, developed pulpal necrosis with apical periodontitis. After the access cavity preparation, the canal was effectively irrigated with 20 ml of 5.25% sodium hypochlorite solution and 10ml of 0.2% chlorhexidine solution and dried with paper points. Triple antibiotic paste was placed inside the canal and left for 21 days. 12 ml of whole blood was drawn from the patient's right antecubital vein and centrifuged for 10 minutes to obtain the Choukroun's PRF. After the removal of the triple antibiotic paste, the PRF was placed into the canal till the level of cementoenamel junction and 3mm of grey MTA was placed directly over the PRF clot. The setting of MTA was confirmed 3 days later and the tooth was double sealed with GIC and Composite restoration. After 1 year the clinical examination revealed negative responses to percussion and palpation tests. The tooth responded positively to cold and electric pulp tests. Radiographic examination revealed continued thickening of the dentinal walls, root lengthening, regression of the periapical lesion and apical closure. On the basis of the results obtained in our case report we conclude that revitalization of necrotic infected immature tooth is possible under conditions of total canal disinfection and PRF is an ideal biomaterial for pulp-dentin complex regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.