ArticleIndian journal of pharmacology
Effect of Tinospora cordifolia on experimental diabetic neuropathy.
Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 61 citations in OpenAlex.
- From Plant Chemistry to Reproducible Antidiabetic Products: A Critical Review of Molecular Targets, Clinical Evidence, and Translational Gaps.Molecules (Basel, Switzerland) · 2026Review
- Traditional antidiabetic medicinal plants of Himachal Pradesh: ethnomedicinal evidence and drug-discovery potential.Frontiers in nutrition · 2026Review
- Natural therapy proposed for the management of diabetic peripheral neuropathy (DPN).Inflammopharmacology · 2025Review
- Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach.Biogerontology · 2025Article
- Indian herbHeliyon · 2024Review
- Article
- Analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices.BMC complementary and alternative medicine · 2015Article
- Antioxidant strategies in the management of diabetic neuropathy.BioMed research international · 2015Review
- Treating type 2 diabetes mellitus with traditional chinese and Indian medicinal herbs.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Aqueous ethanolic extract of Tinospora cordifolia as a potential candidate for differentiation based therapy of glioblastomas.PloS one · 2013Article
- Article
- Quantification of Quercetin Obtained fromPharmacognosy researchArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effect of aqueous extract of stem of Tinospora cordifolia (TC) on hyperalgesia in streptozotocin induced diabetic rats and in- vitro aldose reductase inhibition. MATERIALS AND
methodsWistar albino rats, rendered diabetic with streptozotocin, were divided into 5 groups, namely the diabetic control treated with vehicle (DC), standard control which received glibenclamide+metformin (SC), test groups treated with 100, 200and 400 mg/kg b.w. of Tinospora cordifolia (TC1, TC2 and TC3 respectively). A group of five normal animals served as normal control (NC). Fasting blood glucose, body weight and reaction time to tail flick were measured one week after induction of diabetes. The animals were then treated orally for two weeks after which the same parameters were repeated. In-vitro aldose reductase inhibition assay was carried out at concentrations of 5, 10, 25, 50, 100 and 200 mcg/ml of Tinospora cordifolia using rat lens from normal rats. The in-vivo results were analysed with Mann Whitney test.
resultsThe DC group demonstrated a decrease in the reaction time (hyperalgesia) compared to NC while a significant increase in the reaction time was observed with SC, TC2 and TC3 groups (p<0.05) as compared to the DC group. TC1 and TC2 showed a significant reduction in body weight compared to their baseline values (p<0.05). There was no significant change in the fasting blood glucose (FBS) in any of the groups. In-vitro aldose reductase inhibition was observed with TC with an IC(50) of 103 mcg/ml.
conclusionsTinospora cordifolia prevents the hyperalgesia in experimental diabetic neuropathy. It has an aldose reductase inhibitory activity in-vitro which may contribute to the beneficial effects.
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