Trial reportSexually transmitted infections2013
Male circumcision reduces penile high-risk human papillomavirus viral load in a randomised clinical trial in Rakai, Uganda.
Trial report in Sexually transmitted infections, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Critical evaluation of arguments opposing male circumcision: A systematic review.Journal of evidence-based medicine · 2019Pooled it
- Cervical cancer prevention and treatment research in Africa: a systematic review from a public health perspective.BMC women's health · 2016Pooled it
- Acquisition and persistence of human papillomavirus 16 (HPV-16) and HPV-18 among men with high-HPV viral load infections in a circumcision trial in Kisumu, Kenya.The Journal of infectious diseases · 2015Trial
- Male circumcision decreases high-risk human papillomavirus viral load in female partners: a randomized trial in Rakai, Uganda.International journal of cancer · 2013Trial
- Novel penile circumcision suturing devices versus the shang ring for adult male circumcision: a prospective study.International braz j urol : official journal of the Brazilian Society of UrologyTrial
- Penile human papilloma virus (HPV) in high risk populations with and without HIV: Epidemiological insights from Argentina.International journal of STD & AIDS · 2026Article
- Does the evidence support circumcision of infant males in the United Kingdom?-a systematic review.Translational andrology and urology · 2026Review
- Male Circumcision and Genital Human Papillomavirus (HPV) Infection in Males and Their Female Sexual Partners: Findings From the HPV Infection and Transmission Among Couples Through Heterosexual Activity (HITCH) Cohort Study.The Journal of infectious diseases · 2022Article
- Evidence-based circumcision policy for Australia.Journal of men's health · 2022Article
- A Framework for Cervical Cancer Elimination in Low-and-Middle-Income Countries: A Scoping Review and Roadmap for Interventions and Research Priorities.Frontiers in public health · 2021Article
- Long-term Persistence of Oral HPV Over 7 Years of Follow-up.JNCI cancer spectrum · 2020Article
- Anogenital Human Papillomavirus and HIV Infection in Rwandan Men Who Have Sex With Men.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?Frontiers in public health · 2019Article
- Females' Peer Influence and Support for Adolescent Males Receiving Voluntary Medical Male Circumcision Services.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Relationship between human papillomavirus and penile cancer-implications for prevention and treatment.Translational andrology and urology · 2017Review
- Trends and Determinants of Human Papillomavirus Concordance Among Human Immunodeficiency Virus-Positive and -Negative Heterosexual Couples in Rakai, Uganda.The Journal of infectious diseases · 2017Article
- Early infant male circumcision: Systematic review, risk-benefit analysis, and progress in policy.World journal of clinical pediatrics · 2017Article
- Critical evaluation of unscientific arguments disparaging affirmative infant male circumcision policy.World journal of clinical pediatrics · 2016Article
- Partner Human Papillomavirus Viral Load and Incident Human Papillomavirus Detection in Heterosexual Couples.The Journal of infectious diseases · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesMale circumcision reduces penile high-risk human papillomavirus (HR-HPV) prevalence in randomised trials. The goal of this study was to examine the effect of circumcision on HPV viral load among HPV-infected men in a randomised trial of male circumcision.
methodsIn a randomised trial to assess the efficacy of circumcision on HIV acquisition in Rakai, Uganda, HIV-negative men were randomised to immediate (intervention) or delayed (control) circumcision and followed over 24 months. We performed quantitative-PCR HPV viral load assays on penile swabs which tested positive by Linear Array (LA) for six HR-HPV genotypes and estimated viral load in the remaining types by LA signal strength.
resultsAt 24 months, circumcision intervention arm men infected with one of the six selected HR-HPV genotypes had a lower viral load and significantly reduced HR-HPV high LA band intensity (PRR=0.61, 95% CI 0.43 to 0.86) compared to infected men in the control arm of the trial. The decreased viral load associated with circumcision was seen among HPV infections acquired after enrolment but not among infections that persisted from trial enrolment to 24 months (p=0.80).
conclusionsThe decreased penile HR-HPV shedding observed among HPV-infected circumcised men may help to explain the protective association observed between circumcision and reduced acquisition of HR-HPV in female partners.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.