ArticleScience (New York, N.Y.)2012
Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 187 citations in OpenAlex.
- Article
- Harnessing microbial tools: Escherichia coli as a vehicle for neuropeptide functional analysis in Caenorhabditis elegans.Genetics · 2026Article
- Intercellular sphingolipid signaling mediates aversive learning in C. elegans.Current biology : CB · 2025Article
- Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory.iScience · 2025Article
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Identification and Targeted Quantification of Endogenous Neuropeptides in the Nematode Caenorhabditis elegans Using Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The neuropeptidergic connectome of C. elegans.Neuron · 2023Article
- System-wide mapping of peptide-GPCR interactions in C. elegans.Cell reports · 2023Article
- A Putative Role of Vasopressin/Oxytocin-Type Neuropeptide in Osmoregulation and Feeding Inhibition ofInternational journal of molecular sciences · 2023Article
- The Long Way of Oxytocin from the Uterus to the Heart in 70 Years from Its Discovery.International journal of molecular sciences · 2023Review
- Making "Sense" of Ecology from a Genetic Perspective:Metabolites · 2022Review
- Article
- Neuropeptide signalling shapes feeding and reproductive behaviours in maleLife science alliance · 2022Article
- Ptchd1 mediates opioid tolerance via cholesterol-dependent effects on μ-opioid receptor trafficking.Nature neuroscience · 2022Article
- Oxytocin receptor expression patterns in the human brain across development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Vasopressin-oxytocin-type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians.Science advances · 2022Article
- Oxytocin-pathway polygenic scores for severe mental disorders and metabolic phenotypes in the UK Biobank.Translational psychiatry · 2021Article
- Plasticity in gustatory and nociceptive neurons controls decision making in C. elegans salt navigation.Communications biology · 2021Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasopressin- and oxytocin-related neuropeptides are key regulators of animal physiology, including water balance and reproduction. Although these neuropeptides also modulate social behavior and cognition in mammals, the mechanism for influencing behavioral plasticity and the evolutionary origin of these effects are not well understood. Here, we present a functional vasopressin- and oxytocin-like signaling system in the nematode Caenorhabditis elegans. Through activation of its receptor NTR-1, a vasopressin/oxytocin-related neuropeptide, designated nematocin, facilitates the experience-driven modulation of salt chemotaxis, a type of gustatory associative learning in C. elegans. Our study suggests that vasopressin and oxytocin neuropeptides have ancient roles in modulating sensory processing in neural circuits that underlie behavioral plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.